ReviewAnnals of the New York Academy of Sciences2026
Intra-Islet Paracrine Regulation of Glucagon Secretion During Hypoglycemia, Euglycemia, and Hyperglycemia.
Review in Annals of the New York Academy of Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
The regulation of glucagon and insulin secretion, from pancreatic α- and β-cells, respectively, is essential for maintaining blood glucose within the physiological set point. Insulin secretion is stimulated as glucose rises from euglycemia, with incretin hormones modulating the secretion in a glucose-dependent manner. Glucagon secretion is elevated with hypoglycemia but also with hyperglycemia. Within the pancreatic islet, α-cell glucagon output is regulated by complex neuroendocrine and paracrine signals from insulin-releasing β-cells and somatostatin-secreting δ-cells. This network of intra-islet crosstalk tunes glucagon secretion in response to changes in glucose levels. In diabetes, intra-islet paracrine crosstalk between
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