Evidence map›Paper›PMID 42736366›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Deletion of N-ethylmaleimide-sensitive factor in dopamine D2 receptor-expressing cells impairs striatal development and dopaminergic function and induces ADHD-like behaviors in mice.

Min-Jue Xie, Koshi Murata, Hiroshi Kuniishi, Yugo Fukazawa, Noriyoshi Usui, Hideo Matsuzaki

Abstract read
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Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Min-Jue Xie *Division of Development of Mental Functions, Research Centre for Child Mental Development, University of Fukui, Fukui, 910-1193, Japan. mjxie@u-fukui.ac.jp.
Koshi Murata *Life Science Innovation Centre, University of Fukui, Fukui, 910-1193, Japan.ORCID http://orcid.org/0000-0002-6425-3053
Hiroshi KuniishiDivision of Development of Mental Functions, Research Centre for Child Mental Development, University of Fukui, Fukui, 910-1193, Japan.
Yugo FukazawaLife Science Innovation Centre, University of Fukui, Fukui, 910-1193, Japan.ORCID http://orcid.org/0000-0001-7436-8797
Noriyoshi UsuiDivision of Development of Mental Functions, Research Centre for Child Mental Development, University of Fukui, Fukui, 910-1193, Japan.ORCID http://orcid.org/0000-0001-8079-8013
Hideo MatsuzakiDivision of Development of Mental Functions, Research Centre for Child Mental Development, University of Fukui, Fukui, 910-1193, Japan.ORCID http://orcid.org/0000-0002-6869-1261

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 16H05373MEXT | Japan Society for the Promotion of Science (JSPS) 24K02131
6 · The paper itself

Abstract

N-ethylmaleimide-sensitive factor (NSF) regulates membrane fusion, supporting neurotransmitter release and membrane protein trafficking. NSF dysfunction has been linked to neuropsychiatric disorders. Although NSF interacts with dopamine D2 receptor (D2R), and NSF reduction induces excitotoxicity in vitro, its role in D2R-expressing cells in vivo remains unclear. This study examined the effects of NSF loss on D2R-expressing cell populations and mouse behaviors. We generated D2R-specific NSF conditional knockout (Nsf

Identifiers

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.