ArticleFoods (Basel, Switzerland)2026
Metabolic Profile and Dynamic Characteristics of Ziziphi Spinosae Semen Flavonoids During Biotransformation and Their Effect on Human Gut Microbiota In Vitro.
Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The Ziziphi spinosae semen flavonoids (ZSSF) possess significant nutritional value and exhibit a wide range of health benefits, exerting positive effects on diseases related to the central nervous system. Given the excellent bioactivity and limited absorption of ZSSF, elucidating the underlying mechanism of ZSSF is imperative. In this study, in vitro fecal microbial culture fermentation was performed to investigate the metabolism of ZSSF and its effect on the gut microbiota. A total of 45 chemical constituents were identified by Ultra-performance liquid chromatography-quadrupole time-of-flight-tandem mass spectrometry (UPLC-Q-TOF-MS/MS), and possible biotransformation pathways were postulated. The degradation rates of spinosin and 6‴-feruloylspinosin were 2.53 ± 0.07 μg/mL/h and 0.79 ± 0.06 μg/mL/h, respectively, with swertisin accumulating to 55.00 ± 3.55 μg/mL at 24 h before declining. The abundance of
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