SynthesisInternational journal of molecular sciences2026
Preoperative Inflammatory Blood Indices as Prognostic Markers in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.
Synthesis in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
Oral squamous cell carcinoma (OSCC) prognosis remains limited by TNM staging alone. We conducted a systematic review and meta-analysis to evaluate preoperative neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR) and lymphocyte-to-monocyte (LMR) ratios as prognostic markers. We searched PubMed/MEDLINE, Scopus, Base, Google Scholar and ScienceDirect from inception to 30 May 2026. Eligible studies reported preoperative ratios and survival outcomes, namely, overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS), in surgically treated OSCC. Risk of bias was assessed with the QUIPS tool. Random-effects meta-analyses of multivariate hazard ratios (HRs) were primary; univariate data, heterogeneity, prediction intervals, sensitivity and subgroup analyses were also performed. Thirty-nine studies (12,153 patients; mostly East Asian retrospective cohorts) were included. Elevated NLR predicted worse overall survival (HR 1.51, 95% CI 1.32-1.73) and disease-specific survival (HR 2.00, 1.58-2.54). NLR also showed a significant association with DFS (HR = 1.47, 95% CI: 1.21-1.78), though the prediction interval crossed unity. PLR and LMR showed weaker, less consistent associations. Evidence was limited by predominant retrospective design, geographic concentration and variable cut-offs. Preoperative NLR is a reproducible, inexpensive prognostic biomarker that may complement TNM staging; standardized thresholds require prospective validation. The review was registered in PROSPERO; no specific funding was received.
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