Evidence map›Paper›PMID 42737553›Full record

ArticleInternational journal of molecular sciences2026

Differential Diagnosis of Anemia Using the Erythrocyte Filterability Method.

Elena I Sinauridze, Elizaveta A Bovt, Dmitry S Prudinnik, Ivan A Dolgikh, Larisa Koleva, Soslan S Shakhidzhanov, Nikita S Kushnir, Anna S Suvorova, Evgeniy S Protasov, Evgeniya A Brovkina and 5 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Elena I SinauridzeDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Healthcare, Samora Machel Street, 1, GSP-7, Moscow 117198, Russia.ORCID 0000-0002-5948-3444
Elizaveta A BovtDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Healthcare, Samora Machel Street, 1, GSP-7, Moscow 117198, Russia.
Dmitry S PrudinnikDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Healthcare, Samora Machel Street, 1, GSP-7, Moscow 117198, Russia.ORCID 0000-0001-5995-7702
Ivan A DolgikhDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Healthcare, Samora Machel Street, 1, GSP-7, Moscow 117198, Russia.
Larisa KolevaDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Healthcare, Samora Machel Street, 1, GSP-7, Moscow 117198, Russia.ORCID 0000-0001-8803-5694
Soslan S ShakhidzhanovDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Healthcare, Samora Machel Street, 1, GSP-7, Moscow 117198, Russia.
Nikita S KushnirDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Healthcare, Samora Machel Street, 1, GSP-7, Moscow 117198, Russia.ORCID 0009-0003-8800-6465
Anna S SuvorovaDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Healthcare, Samora Machel Street, 1, GSP-7, Moscow 117198, Russia.ORCID 0009-0004-9565-5591
Evgeniy S ProtasovDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Healthcare, Samora Machel Street, 1, GSP-7, Moscow 117198, Russia.
Evgeniya A BrovkinaDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Healthcare, Samora Machel Street, 1, GSP-7, Moscow 117198, Russia.ORCID 0009-0009-2153-5809
Ivan A ChabinDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Healthcare, Samora Machel Street, 1, GSP-7, Moscow 117198, Russia.ORCID 0000-0003-0625-1743
Svetlana G KapranovaDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Healthcare, Samora Machel Street, 1, GSP-7, Moscow 117198, Russia.ORCID 0000-0002-1014-5196
Svetlana A PlyasunovaDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Healthcare, Samora Machel Street, 1, GSP-7, Moscow 117198, Russia.
Nataliya S SmetaninaDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Healthcare, Samora Machel Street, 1, GSP-7, Moscow 117198, Russia.ORCID 0000-0002-8805-1499
Fazoil I AtaullakhanovCenter for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Srednyaya Kalitnikovskaya Street, 30, Moscow 109029, Russia.

Funding

Russian Science Foundation 25-25-00998
6 · The paper itself

Abstract

Hereditary hemolytic anemias (HHAs) have very similar clinical manifestations, complicating differential diagnosis and determining treatment strategies, such as splenectomy. To differentiate between hereditary spherocytosis (HS), pyruvate kinase deficiency (PKD), and hereditary stomatocytosis (HSt), we proposed measuring erythrocyte filterability using membrane filters with a pore diameter of 3 or 3.5 μm. Our modified method provides improved reproducibility, reducing the scattering in results caused by differences in the filters used. Erythrocytes' filterability differs significantly between patients with HS, HSt, and PKD (medians and 95% confidence intervals were 0.025 [0.004; 0.100] (

Indexed as

Anemia, Hemolytic, CongenitalAnemia, Hemolytic, Congenital NonspherocyticErythrocytesPyruvate Metabolism, Inborn ErrorsSpherocytosis, HereditaryDiagnosis, DifferentialFemaleFiltrationHumansMalePyruvate KinaseReproducibility of ResultsSensitivity and SpecificityPyruvate Kinasedifferential diagnosisEMA testfilterability of erythrocyteshereditary hemolytic anemiahereditary spherocytosishereditary stomatocytosisosmotic resistance of erythrocytespyruvate kinase deficiencyred blood cellsphericity index

Identifiers

PMID42737553
PMCPMC13566791

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.