A Cross-Sectional Exploratory Study of Endothelial Biomarkers in Non-Obese Women with and Without Polyendocrine Metabolic Ovarian Syndrome.

Manjula Nandakumar, Sana Waris, Thozhukat Sathyapalan, Alexandra E Butler, Stephen L Atkin

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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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2 · The registry

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5 · Who and what money

Authors and funding

5 authors.

Manjula NandakumarResearch Department, Royal College of Surgeons in Ireland, Medical University in Bahrain, Adliya P.O. Box 15503, Bahrain.

Sana WarisResearch Department, Royal College of Surgeons in Ireland, Medical University in Bahrain, Adliya P.O. Box 15503, Bahrain.

Thozhukat SathyapalanAcademic Endocrinology, Diabetes and Metabolism, Hull York Medical School, Hull HU6 7RX, UK.ORCID 0000-0003-3544-2231

Alexandra E ButlerResearch Department, Royal College of Surgeons in Ireland, Medical University in Bahrain, Adliya P.O. Box 15503, Bahrain.ORCID 0000-0002-5762-3917

Stephen L AtkinResearch Department, Royal College of Surgeons in Ireland, Medical University in Bahrain, Adliya P.O. Box 15503, Bahrain.ORCID 0000-0002-5887-7257

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelial dysfunction has been reported in polyendocrine metabolic ovarian syndrome (PMOS) and is associated with obesity. We hypothesised that circulating biomarkers of endothelial dysfunction would not differ between non-obese women with PMOS and age- and BMI-matched controls in the absence of major between-group differences in insulin resistance (IR), systemic inflammation or vitamin D status. Plasma concentrations of 20 endothelial-associated proteins were measured using Slow Off-rate Modified Aptamer (SOMAscan) technology in 29 non-obese women with PMOS and 29 age- and BMI-matched controls. Women with PMOS had higher Ferriman-Gallwey scores, free androgen index (FAI) and anti-Müllerian hormone (AMH), whereas HOMA-IR, C-reactive protein (CRP), vitamin D metabolites and endothelial-associated biomarkers did not differ significantly between groups. Within the PMOS cohort, FAI was strongly positively associated with E-selectin (Pearson

Indexed as

BiomarkersEndothelium, VascularMetabolic SyndromeAdultCross-Sectional StudiesFemaleHumansInsulin ResistanceMiddle AgedBiomarkersbiomarkerscardiovascular riskendotheliumPMOSpolyendocrine metabolic ovary syndromeVEGFvitamin D

Identifiers

PMID42737559

DOI10.3390/ijms27177661

PMCPMC13566641

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.