Exploratory Toxicogenomic Profiling Identifies Candidate DINCH-Responsive Genes Relevant to Prostate Cancer.

Chi-Fen Chang, Wen-Hsin Lin, Chao-Yuan Huang, Chia-Cheng Yu, Victor C Lin, Te-Ling Lu, Shu-Pin Huang, Bo-Ying Bao

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Chi-Fen ChangDepartment of Anatomy, School of Medicine, China Medical University, Taichung 406, Taiwan.

Wen-Hsin LinDepartment of Pharmacy, China Medical University, Taichung 406, Taiwan.ORCID 0000-0002-7216-1626

Chao-Yuan HuangDepartment of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

Chia-Cheng YuDivision of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan.ORCID 0000-0002-2620-1914

Victor C LinDepartment of Urology, E-Da Hospital, Kaohsiung 824, Taiwan.

Te-Ling LuDepartment of Pharmacy, China Medical University, Taichung 406, Taiwan.ORCID 0000-0003-1408-6004

Shu-Pin HuangGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Bo-Ying BaoDepartment of Pharmacy, China Medical University, Taichung 406, Taiwan.ORCID 0000-0001-5510-6513

Funding

China Medical University CMU111-MF-09, CMU112-MF-10, CMU113-TC-04, CMU113-MF-11, CMU114-S-50, and CMU114-MF-80Kaohsiung Medical University KMUH112-2R59, KMUH113-3R52, KMUH114-4M54, and KMUH114-4R59National Science and Technology Council 110-2314-B-002-113, 111-2314-B-002-240-MY3, 111-2320-B-039-021-MY3, 111-2218-E-037-001, 112-2218-E-037-001, 113-2218-E-037-001, 112-2314-B-037-127, 113-2314-B-037-016, and 114-2320-B-039-024-MY3

6 · The paper itself

Abstract

Diisononyl cyclohexane-1,2-dicarboxylate (DINCH), a non-phthalate plasticizer adopted as a safer alternative for food-contact and medical-grade materials, is ubiquitously detected in human biomonitoring studies. Despite widespread exposure, its transcriptional effects in prostate cells and the potential prostate cancer relevance of DINCH-responsive genes remain unclear. We integrated transcriptomic profiling of DINCH-exposed human prostate epithelial cells with exploratory genetic association analyses in 630 patients with prostate cancer receiving androgen deprivation therapy (ADT). Haplotype-tagged single-nucleotide polymorphisms (SNPs) in candidate DINCH-responsive genes were evaluated for their association with overall survival (OS) and cancer-specific survival (CSS). The prostate cancer relevance of the prioritized genes was further validated using pooled multi-cohort bioinformatic analyses. DINCH exposure produced an exploratory molecular signature comprising 83 genes across all tested doses, broadly suppressing cell-matrix adhesion pathways and activating chromatin remodeling. Exploratory genetic screening identified nominal associations of

Indexed as

Gene Expression Regulation, NeoplasticProstatic NeoplasmsToxicogeneticsGene Expression ProfilingHumansMalePolymorphism, Single NucleotideTranscriptomeDINCHplasticizerprostate cancertoxicogenomicstranscriptomics

Identifiers

PMID42737583

DOI10.3390/ijms27177686

PMCPMC13566863

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.