Evidence map›Paper›PMID 42737586›Full record

ReviewInternational journal of molecular sciences2026

Impact of Microgravity on Cytoskeletal Dynamics, Protein Transport, and Signaling Networks: Potential Therapeutic Opportunities for Skin Health.

Jamison M Ballard, Rishitha Chiguru, Matthew B Deeb, Rebecca B Swatsburg, Ada Y Lau, Grace H Davis, Mevlana Demiri, Jewelia T Keller, Beder Nourachi, Tasnim A Abu Shihadeh and 10 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jamison M BallardDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.
Rishitha ChiguruDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.
Matthew B DeebDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.
Rebecca B SwatsburgDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.
Ada Y LauDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.
Grace H DavisDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.
Mevlana DemiriDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.
Jewelia T KellerDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.
Beder NourachiDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.ORCID 0009-0000-4351-9759
Tasnim A Abu ShihadehDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.
Rylin SchneiderDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.
Ericka ArticuloDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.
Naja M DayeDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.
Tasneem A AwwadDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.ORCID 0009-0007-0097-404X
Brianna LamkoDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.
Samantha M BaileyDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.
Bella L GuerraDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.
Shayna L GuerraDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.
Corissa QuartermanDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.
Meera NanjundanDepartment of Molecular Biosciences, University of South Florida, 4202 East Fowler Avenue, ISA2015, Tampa, FL 33620, USA.ORCID 0000-0002-7485-3212

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astronauts encounter several challenges on spaceflight missions, including space radiation and microgravity. Over the past several decades, studies conducted in the field of space medicine have uncovered broad impacts on human physiology, including the integumentary system, which serves as a protective barrier to environmental factors. Dermatological alterations in astronauts are commonly observed during spaceflight missions. Advancing our understanding of the intracellular mechanisms impacted in skin within the context of microgravity may uncover potential therapies for maintaining and improving skin health. Towards this goal, we utilized PubMed to survey current findings relevant to microgravity effects on cytoskeletal components, intracellular protein trafficking, and signaling cascades in mammalian model systems, in addition to identifying gaps in current knowledge. Concurrently across these studies, we focused on the specific cell culture technologies that were utilized during spaceflight missions and in microgravity simulated conditions. Altogether, we envision that these mechanistic insights will contribute to a better understanding of skin disorders such as atopic dermatitis and psoriasis, for which current treatment regimens are associated with adverse responses. Furthermore, the identified knowledge gaps will unveil new avenues for future spaceflight research to further propel scientific advancements in the field of space medicine.

Indexed as

CytoskeletonSignal TransductionSkinWeightlessnessAnimalsHumansProtein TransportSkin DiseasesSpace Flightcytoskeletondermatologymicrogravityprotein traffickingsignalingskinspace medicine

Identifiers

PMID42737586
PMCPMC13565916

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.