Evidence map›Paper›PMID 42737587›Full record

ReviewInternational journal of molecular sciences2026

Paclitaxel Nanomedicines: Molecular Mechanisms of Drug Resistance, Tumor Microenvironment-Responsive Delivery, and Translational Challenges.

Dejun Cheng, Guowei Yang, Ruibin Kong, Qin Liu, Li Li, Yunpeng Luan, Qijiang Shu

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dejun ChengInstitute of Information, Yunnan University of Chinese Medicine, Kunming 650500, China.ORCID 0009-0001-9432-4844
Guowei YangInstitute of Information, Yunnan University of Chinese Medicine, Kunming 650500, China.ORCID 0009-0009-7886-1453
Ruibin KongInstitute of Information, Yunnan University of Chinese Medicine, Kunming 650500, China.ORCID 0009-0004-1869-1206
Qin LiuCollege of Nursing, Yunnan University of Chinese Medicine, Kunming 650500, China.
Li LiKey Laboratory of Traditional Chinese Medicine for the Prevention and Treatment of Gastrointestinal Diseases, Yunnan Provincial Department of Education, Kunming 650500, China.
Yunpeng LuanKey Laboratory of Traditional Chinese Medicine for the Prevention and Treatment of Gastrointestinal Diseases, Yunnan Provincial Department of Education, Kunming 650500, China.
Qijiang ShuInstitute of Information, Yunnan University of Chinese Medicine, Kunming 650500, China.ORCID 0000-0003-2038-5406

Funding

Basic Research Project of Yunnan Province 202501AT070335National Natural Science Foundation of China 32160223National Natural Science Foundation of China 82460988TCM Joint Project of Yunnan Province 202301AZ070001-033
6 · The paper itself

Abstract

Paclitaxel (PTX) remains a major component of treatment for solid tumors, but its clinical performance is limited by poor aqueous solubility, solvent-associated toxicity, heterogeneous tumor exposure, and multifactorial drug resistance. This narrative review examines PTX nanomedicines from a molecular pharmacology perspective, focusing on how carrier design interacts with resistance pathways, tumor microenvironment signals, and intracellular drug trafficking. We outline resistance mechanisms involving ATP-binding cassette subfamily B member 1 (

Indexed as

Antineoplastic Agents, PhytogenicDrug Resistance, NeoplasmNanomedicineNeoplasmsPaclitaxelTumor MicroenvironmentAnimalsDrug Delivery SystemsHumansAntineoplastic Agents, PhytogenicPaclitaxelclinical translationdrug deliverymachine learningmultidrug resistancenanomedicinepaclitaxelpharmaceutical formulationtumor microenvironment

Identifiers

PMID42737587
PMCPMC13566125

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.