Evidence map›Paper›PMID 42737609›Full record

ReviewInternational journal of molecular sciences2026

The Zinc-Senescence Axis in Skin Aging and Wound Healing: A Narrative Review.

Kerim Mutig, Prim B Singh, Dulat Azhibek, Svetlana Lebedeva

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kerim MutigDepartment of Biosciences, School of Medicine, Nazarbayev University, Astana 010000, Kazakhstan.
Prim B SinghDepartment of Biosciences, School of Medicine, Nazarbayev University, Astana 010000, Kazakhstan.ORCID 0000-0002-9571-0974
Dulat AzhibekDepartment of Biosciences, School of Medicine, Nazarbayev University, Astana 010000, Kazakhstan.
Svetlana LebedevaDepartment of Pharmacology, Institute of Pharmacy Named After A.P. Nelyubin, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.ORCID 0000-0001-8769-1040

Funding

Committee of Ministry of Science and Higher Education of the Republic of Kazakhstan "Prolonging healthy longevity: using new technologies and machine learning to control reversal of aging in old cells" BR24992900
6 · The paper itself

Abstract

Approximately one billion people worldwide are affected by acute or chronic skin wounds, placing a substantial burden on healthcare systems. This burden is further increased by population aging, as wound healing is impaired in older individuals due to age-related changes in tissue repair. Structural and functional skin alterations associated with aging and wound healing have been extensively described, including cellular senescence and inflammaging. However, less is known about zinc homeostasis in aged skin and its impact on skin regeneration in aging. Zinc deficiency, which is common in older adults, may impair wound healing and contribute to the development of chronic wounds. The present review focuses on the age-related alterations of zinc homeostasis in the skin and the role of zinc in skin regeneration and wound healing.

Indexed as

Cellular SenescenceSkin AgingWound HealingZincAgingAnimalsHomeostasisHumansSkinZinccellular senescenceinflammationSASPskin agingwound healingzinc

Identifiers

PMID42737609
PMCPMC13566430

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.