Phenytoin Derivatives as Antagonists of AMPA Receptors and Voltage-Gated Sodium Channels: A Structure-Function Study.

Arseniy S Zhigulin, Maxim V Nikolaev, Mikhail Y Dron, Dmitry A Vasilenko, Oleg I Barygin, Denis B Tikhonov

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Arseniy S ZhigulinSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223 Saint Petersburg, Russia.

Maxim V NikolaevSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223 Saint Petersburg, Russia.

Mikhail Y DronSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223 Saint Petersburg, Russia.

Dmitry A VasilenkoDepartment of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.

Oleg I BaryginSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223 Saint Petersburg, Russia.ORCID 0000-0002-4197-3277

Denis B TikhonovSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223 Saint Petersburg, Russia.ORCID 0000-0001-8523-4305

Funding

The Ministry of Education and Science of the Russian Federation 075-15-2024-548

6 · The paper itself

Abstract

The development of antiepileptic drugs remains a serious challenge for both academia and industry. Ionotropic glutamate receptors and voltage-gated sodium channels are among the primary targets of antiepileptic agents. Recent studies have revealed a unique property of phenytoin: unlike other sodium-channel blockers, it inhibits calcium-impermeable AMPA receptors at micromolar concentrations. In this study, we explored the structure-activity relationships of eight phenytoin derivatives. The effects of the compounds on neuronal voltage-gated Na

Indexed as

PhenytoinReceptors, AMPAVoltage-Gated Sodium Channel BlockersVoltage-Gated Sodium ChannelsAnimalsAnticonvulsantsHumansPatch-Clamp TechniquesStructure-Activity RelationshipAnticonvulsantsPhenytoinReceptors, AMPAVoltage-Gated Sodium Channel BlockersVoltage-Gated Sodium ChannelsAMPA receptorspore blocksodium channelsstructure–function relationshipsuse-dependence

Identifiers

PMID42737620

DOI10.3390/ijms27177723

PMCPMC13566764

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.