Evidence map›Paper›PMID 42737621›Full record

ArticleInternational journal of molecular sciences2026

Targeting Insulin Signaling and TRAF2/JNK Pathway: A Comprehensive In Silico Study of

Bruna Freitas Marchi, Shraddha Parate, Vibhu Jha, Felipe Santiago Chambergo, Leif A Eriksson, Viviane Abreu Nunes

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bruna Freitas MarchiDepartment of Chemistry and Molecular Biology, University of Gothenburg (GU), 41390 Göteborg, Sweden.
Shraddha ParateDepartment of Life Sciences, Chalmers University of Technology, 41296 Göteborg, Sweden.
Vibhu JhaInstitute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, University of Bradford, Bradford BD7 1DP, UK.ORCID 0000-0002-1168-7480
Felipe Santiago ChambergoLaboratory of Skin Physiology and Tissue Bioengineering, School of Arts, Sciences and Humanities, University of Sao Paulo (EACH-USP), São Paulo 03828-000, SP, Brazil.ORCID 0000-0001-7567-0656
Leif A ErikssonDepartment of Chemistry and Molecular Biology, University of Gothenburg (GU), 41390 Göteborg, Sweden.ORCID 0000-0001-5654-3109
Viviane Abreu NunesLaboratory of Skin Physiology and Tissue Bioengineering, School of Arts, Sciences and Humanities, University of Sao Paulo (EACH-USP), São Paulo 03828-000, SP, Brazil.ORCID 0000-0003-0861-4392

Funding

National Council for Scientific and Technological Development 200473/2022-0São Paulo Research Foundation 22/16702-3Sven and Lilly Lawski Foundation N2024-0035Swedish Research Council 2022-06725
6 · The paper itself

Abstract

Type 2 diabetes (T2D) is a metabolic syndrome frequently associated with obesity and endoplasmic reticulum stress-mediated inflammation, which can trigger the unfolded protein response (UPR), impair insulin signaling, and promote apoptosis. To identify potential natural therapeutic candidates, this study investigated the mechanisms of action of 14 compounds from

Indexed as

Cat's ClawInsulinMAP Kinase Signaling SystemPlant ExtractsSignal TransductionTNF Receptor-Associated Factor 2Computer SimulationDiabetes Mellitus, Type 2HumansMolecular Docking SimulationMolecular Dynamics SimulationUnfolded Protein ResponseInsulinPlant ExtractsTNF Receptor-Associated Factor 2in silico modelinginsulin resistancephytochemicalstype 2 diabetesUncaria tomentosaunfolded protein response

Identifiers

PMID42737621
PMCPMC13566028

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.