ArticleInternational journal of molecular sciences2026
Photobiomodulation with 808 nm Laser Light Repairs Mitochondrial Integrity and Normalizes ROS, ATP, and Membrane Depolarization in Aβ-Exposed Primary Neurons in Alzheimer's Disease Model.
Iuliia Golovynska, Binjun Li, Qinglin Chen, Sergii Golovynskyi, Hao Xu, Yurii V Stepanov, Liudmyla I Stepanova, Fangrui Lin, Junle Qu, Tymish Y Ohulchanskyy
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In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
10 authors.
Iuliia GolovynskaShenzhen Key Laboratory of Photonics and Biophotonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0003-3916-6588 Binjun LiShenzhen Key Laboratory of Photonics and Biophotonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Qinglin ChenShenzhen Key Laboratory of Photonics and Biophotonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0009-0005-8706-107X Sergii GolovynskyiShenzhen Key Laboratory of Photonics and Biophotonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0002-1864-976X Hao XuShenzhen Key Laboratory of Photonics and Biophotonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Yurii V StepanovR.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Science of Ukraine, 03022 Kyiv, Ukraine.ORCID 0000-0002-6349-631X Liudmyla I StepanovaInstitute of Biology and Medicine, Taras Shevchenko National University of Kyiv, 01601 Kyiv, Ukraine.
Fangrui LinShenzhen Key Laboratory of Photonics and Biophotonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Junle QuShenzhen Key Laboratory of Photonics and Biophotonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0001-7833-4711 Tymish Y OhulchanskyyShenzhen Key Laboratory of Photonics and Biophotonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0002-7051-6534 Funding
Key Laboratory of Biomedical Optics Micro-Nano Detection and Imaging ZDSY20130329101226215National Natural Science Foundation of China W2431056, 62127819, T2421003, 62435011, 62475163, 62361136586Shenzhen Key Laboratory of Photonics and Biophotonics ZDSYS20210623092006020Shenzhen Science and Technology Innovation Commission JCYJ20220818100202005
6 · The paper itselfAbstract
Alzheimer's disease (AD) is increasingly recognized as a disorder involving profound mitochondrial dysfunction. Although photobiomodulation (PBM) has shown neuroprotective efficacy in experimental AD models, whether restoration of mitochondrial architecture is mechanistically required for these effects remains unknown. Here, we investigated the role of mitochondrial network remodeling in PBM-mediated neuroprotection in primary mouse hippocampal neurons exposed to amyloid-β (Aβ). Neurons were treated for 24 h with oligomeric Aβ
Indexed as
Adenosine TriphosphateAlzheimer DiseaseAmyloid beta-PeptidesLow-Level Light TherapyMitochondriaNeuronsReactive Oxygen SpeciesAnimalsCells, CulturedDisease Models, AnimalHippocampusMembrane Potential, MitochondrialMiceMitochondrial DynamicsPeptide FragmentsAdenosine TriphosphateAmyloid beta-PeptidesPeptide FragmentsReactive Oxygen SpeciesAlzheimer’s diseaseamyloid-βmitochondrial network morphologyneuronsphotobiomodulation
Identifiers
PMID42737733
PMCPMC13565913
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