ArticleInternational journal of molecular sciences2026
Dietary Fiber-Associated Differences in Gut Microbial Community Composition and Predicted Short-Chain Fatty Acid-Related Functional Potential: An In Silico Re-Analysis of 16S rRNA Data.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dietary fiber shapes both gut microbial community structure and the fermentable substrates available to resident taxa, yet how fiber deprivation reshapes taxonomic representation and predicted functional potential remains incompletely resolved. We performed an in silico re-analysis of publicly deposited 16S rRNA gene data from 15 female C57BL/6 mice distributed across three dietary cohorts-fiber-replete (F), no-fiber (NF), and no-fiber with exogenous short-chain fatty acid supplementation (NF-SCFA)-using processed taxonomic profiles and PICRUSt-derived KO/EC and KEGG pathway representations. No new animals, sequencing, enzyme assays, metabolomics, or direct SCFA measurements were generated. The F cohort exhibited the highest alpha-diversity summaries (observed features, Shannon, Simpson) and higher read-count representation for fiber-associated taxa, including Clostridium and Bifidobacterium, whereas NF profiles showed elevated representation of
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