Evidence map›Paper›PMID 42737871›Full record

ArticleInternational journal of molecular sciences2026

Antiparasitic Activity of Sesquiterpene γ-Lactones and the Search for New Pharmaceutical Agents.

Sergazy M Adekenov, Laura C Laurella, Shynggys Sergazy, Rachel Napoles Rodriguez, Augusto E Bivona, Juan M Viecenz, Orlando G Elso, Aldana M Corlatti, Nadia T Mirakian, Esteban Bontempi and 7 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sergazy M AdekenovJSC "Research Production Center "Phytochemistry", 100009 Karaganda, Kazakhstan.ORCID 0000-0001-7588-6174
Laura C LaurellaCONICET-Universidad de Buenos Aires, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Buenos Aires C1113AAD, Argentina.
Shynggys SergazyJSC "Research Production Center "Phytochemistry", 100009 Karaganda, Kazakhstan.ORCID 0000-0002-6030-620X
Rachel Napoles RodriguezUniversidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Farmacognosia, Buenos Aires C1113AAD, Argentina.ORCID 0009-0001-5901-9166
Augusto E BivonaUniversidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Inmunología, Buenos Aires C1113AAD, Argentina.
Juan M ViecenzInstituto Nacional de Parasitología, ANLIS "Carlos G. Malbrán", Buenos Aires C1282AFF, Argentina.ORCID 0000-0002-3592-3951
Orlando G ElsoCONICET-Universidad de Buenos Aires, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Buenos Aires C1113AAD, Argentina.
Aldana M CorlattiCONICET-Universidad de Buenos Aires, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Buenos Aires C1113AAD, Argentina.ORCID 0009-0002-5603-8887
Nadia T MirakianCONICET-Universidad de Buenos Aires, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Buenos Aires C1113AAD, Argentina.
Esteban BontempiInstituto Nacional de Parasitología, ANLIS "Carlos G. Malbrán", Buenos Aires C1282AFF, Argentina.
Paola A BarrosoCONICET-Universidad Nacional de Salta, Instituto de Patología Experimental "Dr. Miguel Ángel Basombrío" (IPE), Salta A4408FVY, Argentina.ORCID 0000-0002-4406-2575
Dmitriy L SavchenkoJSC "Research Production Center "Phytochemistry", 100009 Karaganda, Kazakhstan.ORCID 0009-0000-3955-4869
Balzhan Z MedeubaevaJSC "Research Production Center "Phytochemistry", 100009 Karaganda, Kazakhstan.
Gulimzhan S AdekenovaJSC "Research Production Center "Phytochemistry", 100009 Karaganda, Kazakhstan.
Artur T BoldyshJSC "Research Production Center "Phytochemistry", 100009 Karaganda, Kazakhstan.
Anar N ZhabayevaJSC "Research Production Center "Phytochemistry", 100009 Karaganda, Kazakhstan.
Valeria P SülsenCONICET-Universidad de Buenos Aires, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Buenos Aires C1113AAD, Argentina.ORCID 0000-0002-9322-5748

Funding

Ministry of Science and Higher Education of the Republic of Kazakhstan Fundamental Research Program BR31714779National Agency for Science and Technology Promotion PICT 2020 SERIEA-03061University of Buenos Aires UBACYT 20020220300118BA
6 · The paper itself

Abstract

This study presents a comparative in vitro evaluation of 24 natural sesquiterpene γ-lactones and selected semisynthetic derivatives against three trypanosomatid parasites responsible for neglected tropical diseases:

Indexed as

Antiparasitic AgentsLactonesSesquiterpenesAnimalsHumansLeishmaniaLeishmania mexicanaTrypanosoma brucei bruceiTrypanosoma cruziAntiparasitic AgentsLactonesSesquiterpenesantiparasitic activityLeishmania amazonensissesquiterpene lactonesTrypanosoma brucei bruceiTrypanosoma cruzi

Identifiers

PMID42737871
PMCPMC13565976

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.