Evidence map›Paper›PMID 42738613›Full record

ArticleMolecules (Basel, Switzerland)2026

Improved Lipophilicity Is Associated with the Cytotoxic Activity of Chlorogenic Acid Esters in In Vitro Colorectal Cancer Models.

Ana María Castañeda-Cifuentes, Johanna Pedroza-Díaz, Gloria A Santa-González, Isabel Cristina Henao-Castañeda, Andrea Johanna Andrea Báez, Jorge L Jios, Ana Laura Di Virgilio

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ana María Castañeda-Cifuentesde Investigación e Innovación Biomédica GI2B, Facultad de Ciencias Exactas y Aplicadas, Institución Universitaria ITM, Medellín 050012, Colombia.ORCID 0000-0002-7082-211X
Johanna Pedroza-Díazde Investigación e Innovación Biomédica GI2B, Facultad de Ciencias Exactas y Aplicadas, Institución Universitaria ITM, Medellín 050012, Colombia.ORCID 0000-0002-9784-874X
Gloria A Santa-Gonzálezde Investigación e Innovación Biomédica GI2B, Facultad de Ciencias Exactas y Aplicadas, Institución Universitaria ITM, Medellín 050012, Colombia.ORCID 0000-0003-0514-5957
Isabel Cristina Henao-CastañedaGrupo de Investigación en Sustancias Bioactivas, Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia, Medellín 050010, Colombia.ORCID 0000-0003-1893-2191
Andrea Johanna Andrea BáezGrupo de Investigación en Sustancias Bioactivas, Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia, Medellín 050010, Colombia.
Jorge L JiosLaboratorio UPL (UNLP-CIC), Camino Centenario e/505 y 508 (1897) M.B. Gonnet, Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, República Argentina, 47 esq. 115, La Plata 1900, Buenos Aires, Argentina.ORCID 0000-0001-7812-0043
Ana Laura Di VirgilioCentro de Química Inorgánica (CEQUINOR, CONICET), Facultad de Ciencias Exactas, Universidad Nacional de la Plata Facultad, 47 Y 115, La Plata 1900, Buenos Aires, Argentina.

Funding

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Institución Universitaria ITM P23203NIGMS NIH HHS R01 GM129325
6 · The paper itself

Abstract

Chlorogenic acid (CGA) exhibits anticancer activity in colorectal cancer (CRC), but its clinical application is limited by low lipophilicity. To improve its physicochemical properties, four CGA esters (methyl, ethyl,

Indexed as

Antineoplastic AgentsChlorogenic AcidColorectal NeoplasmsEstersApoptosisCell Line, TumorCell ProliferationCell SurvivalHT29 CellsHumansHydrophobic and Hydrophilic InteractionsMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentsChlorogenic AcidEsterscell deathchlorogenic acidchlorogenic acid esterscolorectal canceresterificationn-butyl chlorogenateoxidative stress

Identifiers

PMID42738613
PMCPMC13567004

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.