Evidence map›Paper›PMID 42738962›Full record

ArticleNutrients2026

Personalised Nutraceutical Treatment Guided by

Cristina Beer, Fiona Rae, Mikayla Watt, Maciej Trzaskowski, Clarissa Yates, Annalese Semmler, Joanne Voisey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cristina BeerCentre for Genomics and Personalised Health, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.
Fiona RaeCentre for Genomics and Personalised Health, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.ORCID 0009-0002-9276-0076
Mikayla WattCris Medical Services, Robina, QLD 4226, Australia.
Maciej TrzaskowskiKetim Technologies, Brisbane City, QLD 4000, Australia.
Clarissa YatesKetim Technologies, Brisbane City, QLD 4000, Australia.ORCID 0000-0002-9578-5634
Annalese SemmlerSchool of Clinical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.ORCID 0000-0002-2084-4986
Joanne VoiseyCentre for Genomics and Personalised Health, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.ORCID 0000-0001-6645-6164

Funding

Research Training Program (RTP) Stipend Scholarship
6 · The paper itself

Abstract

BACKGROUND &

aimsOne-carbon metabolism plays a central role in neurotransmitter synthesis, methylation capacity, and neurobiological resilience. Variants in the methylenetetrahydrofolate reductase (

methodsWe conducted a retrospective cohort study of 50 adults attending an integrative general practice clinic for anxiety and/or depression. All received personalised nutraceutical treatment informed by clinical assessment, laboratory testing and, for 37/50 patients,

resultsAcross the full cohort, mean K10 scores significantly decreased by four points over the treatment period, with 72% of patients showing clinical improvement. Reductions in psychological distress were seen across all

conclusionsIn this real-world primary care cohort, personalised nutraceutical treatment, grounded in one-carbon metabolism support and applied alongside usual care, was associated with clinically meaningful reductions in psychological distress. Outcomes were comparable across

Indexed as

AnxietyAnxiety DisordersDepressionDietary SupplementsMental HealthMethylenetetrahydrofolate Reductase (NADPH2)Precision MedicineAdultFemaleFolic AcidGenotypeHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeFolic AcidMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanL-methylfolateMTHFRnutraceuticalsone-carbon metabolismpersonalised nutritionpsychological distress

Identifiers

PMID42738962
PMCPMC13566919

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.