Evidence map›Paper›PMID 42740466›Full record

ArticlePhysiological reports2026

Glyoxalase 1 loss reduces fatty liver but impairs glucose handling in male mice.

Emely A Hoffman, Aiden M Phoebe, Marissa N Trujillo, Wei Chen Zhang, Erin Q Jennings, Dominique O Farrera, David J Orlicky, Lauren N Rutt, Rebecca L McCullough, Andrea A Huacachino and 7 more

Abstract read
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Emely A HoffmanDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Aiden M PhoebeDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Marissa N TrujilloDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Wei Chen ZhangDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Erin Q JenningsDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Dominique O FarreraDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
David J OrlickyDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Lauren N RuttDepartment of Pharmaceutical Sciences, the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Rebecca L McCulloughDepartment of Pharmaceutical Sciences, the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Andrea A HuacachinoAging & Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Mariola M MarcinkiewiczAging & Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Nathaniel W SnyderAging & Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Kassandra R BrunerDivision of Endocrinology, Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona, USA.
Kimberly Bassoco PayanDivision of Endocrinology, Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona, USA.
Diego Juan Federico MartinezDivision of Endocrinology, Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona, USA.
Jennifer H SternDivision of Endocrinology, Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona, USA.
James J GalliganDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.ORCID https://orcid.org/0000-0002-5612-0680

Funding

CHEMISTRY-BIOLOGY INTERFACE TRAINING PROGRAMT32GM008804 · NIGMS · UNIVERSITY OF ARIZONA · PI MONTFORT, WILLIAM R. · 2003 to 2023
$3.9M
Glyoxalase 1 and its Role in Metabolic SyndromeR01DK133196 · NIDDK · UNIVERSITY OF ARIZONA · PI James J Galligan · 2023 to 2026
$1.8M
Relevance of fatty acid handling in the adaptive response to mitochondrial dysfunctionR01DK138011 · NIDDK · THOMAS JEFFERSON UNIVERSITY · PI Erin Seifert, Nathaniel W. Snyder · 2024 to 2026
$1.6M
Neuroinflammatory GeroMiRs and Alcohol: Defining Mechanisms of ADRDR01AA030741 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI Rebecca LeAnne Smathers McCullough · 2024 to 2026
$1.4M
Measuring compartmentalized metabolism of cofactorsR35GM156596 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI Nathaniel W. Snyder · 2025 to 2026
$555k
Investigating the Role of Wnt3a and Wnt5a as Factors of Hepatic Stellate Cell Activation in Alcohol-Related Liver FibrosisF31AA031426 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI RUTT, LAUREN · 2024 to 2025
$59k
HHS | National Institutes of Health (NIH) F31 AA031426HHS | National Institutes of Health (NIH) R01 AA030741HHS | National Institutes of Health (NIH) R01 DK133196HHS | National Institutes of Health (NIH) R01 DK138011HHS | National Institutes of Health (NIH) R35 GM156596HHS | National Institutes of Health (NIH) T32 GM008804NIAAA NIH HHS F31 AA031426NIAAA NIH HHS R01 AA030741NIDDK NIH HHS R01 DK133196NIDDK NIH HHS R01 DK138011NIGMS NIH HHS R35 GM156596NIGMS NIH HHS T32 GM008804
6 · The paper itself

Abstract

We demonstrate the generation and characterization of the methylglyoxal detoxifying enzyme, glyoxalase 1, knockout mice (Glo1

Indexed as

Blood GlucoseFatty LiverGlucoseLactoylglutathione LyaseAnimalsDiet, High-FatLipid MetabolismLiverMaleMiceMice, Inbred C57BLMice, KnockoutBlood GlucoseGlo1 protein, mouseGlucoseLactoylglutathione LyaseglycationglycolysisglyoxalaseMAFLDmethylglyoxal

Identifiers

PMID42740466
PMCPMC13575502

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.