Evidence map›Paper›PMID 42741072›Full record

ArticleFrontiers in behavioral neuroscience2026

Home-based cognitive telerehabilitation in multiple sclerosis: differential cognitive trajectories according to baseline impairment severity.

Gianna Carla Riccitelli, Rosaria Sacco, Francesca Beeching, Giulia Mallucci, Giulio Disanto, Claudio Gobbi, Chiara Zecca

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In one paragraph

Article in Frontiers in behavioral neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gianna Carla RiccitelliNon-invasive Brain Stimulation Research Unit, Institute of Clinical Neuroscience of Southern Switzerland, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland.
Rosaria SaccoFaculty of Biomedical Sciences, University of Southern Switzerland, Lugano, Switzerland.
Francesca BeechingNon-invasive Brain Stimulation Research Unit, Institute of Clinical Neuroscience of Southern Switzerland, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland.
Giulia MallucciMultiple Sclerosis Center, Institute of Clinical Neuroscience of Southern Switzerland, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland.
Giulio DisantoFaculty of Biomedical Sciences, University of Southern Switzerland, Lugano, Switzerland.
Claudio GobbiNon-invasive Brain Stimulation Research Unit, Institute of Clinical Neuroscience of Southern Switzerland, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland.
Chiara ZeccaFaculty of Biomedical Sciences, University of Southern Switzerland, Lugano, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Although cognitive impairment (CI) is common in multiple sclerosis (MS), conventional cognitive rehabilitation is often limited by accessibility and adherence challenges. Telerehabilitation offers an accessible alternative, but its efficacy across different CI severity levels remains unclear. The present prospective, single-center, single-arm interventional study with repeated measures aimed to identify changes in cognitive and psychosocial outcomes following a home-based cognitive telerehabilitation program with weekly synchronous coaching in MS patients with mild versus moderate CI, and to explore whether baseline impairment severity was associated with differences in change over time. Methods: Sixty-six MS patients (34 mild CI; 32 moderate CI) completed a 12-week home-based cognitive telerehabilitation program (five sessions/week), supported by weekly Skype coaching. Outcomes were assessed at baseline (T0), post-intervention (T1), and 3-month follow-up (T2). Cognitive and emotional-behavioral functioning were investigated using standardized, validated instruments in the MS population. Changes over time and between-group differences were analyzed using linear models. Results: At T1, both groups improved in attention, verbal memory, and subjective cognitive perception (all Conclusion: Following the intervention, both groups showed improvements in cognitive and emotional-behavioral outcomes, with larger and more sustained changes in mild CI. These findings should be confirmed in randomized controlled studies.

Indexed as

cognitive impairmentcognitive rehabilitationmultiple sclerosisneurocognitionquality of lifetelemedicinetelerehabilitation

Identifiers

PMID42741072
PMCPMC13572147

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.