ArticleOsteoarthritis and cartilage open2026
SHIP2 deletion in cartilage does not modulate osteoarthritis in male mice.
Article in Osteoarthritis and cartilage open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Objectives: The inositol phosphatase SHIP2 plays a crucial role in skeletal development and chondrocyte differentiation, and mutations in Methods: A cartilage-specific conditional knockout of SHIP2 was generated using Results: DMM surgery induced OA-like changes in all genotypes, including cartilage damage, synovial inflammation, osteophyte formation, and subchondral bone thickening. However, Conclusion: Despite its known role in cartilage development, SHIP2 deletion in adult cartilage does not affect OA severity or progression in a surgical mouse model. These findings suggest that SHIP2 is not involved in maintaining adult articular cartilage homeostasis and is unlikely to represent a therapeutic target in OA.
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