ReviewBiochemistry and biophysics reports2026
Piezo1-mediated mechanotransduction in bone formation and fracture repair.
Review in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanosensitive ion channel Piezo1 is a crucial transducer of mechanical forces into biological signals governing skeletal development and fracture repair. This review summarizes its central role in bone formation, primarily through endochondral ossification. We detail how Piezo1 regulates key processes including chondrocytes-to-osteoblasts transdifferentiation, osteogenic fate determination in skeletal stem/progenitor cells, and functional activation of mature osteoblasts. Evidence from genetic models demonstrates that Piezo1 deficiency in these cell lineages leads to profound skeletal defects and fragility. Furthermore, Piezo1 is essential for fracture healing, coordinating periosteal stem cell activity, chondrocyte fate and macrophages regulation within the repair callus to enable successful bone regeneration. Finally, we discuss emerging Piezo1-targeted therapeutic strategies, such as low-intensity pulsed ultrasound, biomaterial-based and pharmacological approaches, highlighting its potential as a novel target for treating bone disorders and enhancing fracture repair.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.