Evidence map›Paper›PMID 42741636›Full record

ArticleACS medicinal chemistry letters2026

Molecular Striptease of a Thiadiazolopyrimidine Hit Yields a Streamlined, Artifact-Free NADPH Mimic for NOX Inhibition.

Emanuele Fabbrizi, Andrea Mancini, Chiara Lambona, Salvatore Macrì, Marianna Nalli, Francesco Quilli, Federico Pandolfi, Domenico Raimondo, Sara Marchese, Andrea Mattevi and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Emanuele FabbriziDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Andrea ManciniDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Chiara LambonaDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.ORCID https://orcid.org/0000-0002-3415-4126
Salvatore MacrìDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.ORCID https://orcid.org/0009-0002-5853-9036
Marianna NalliDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Francesco QuilliDepartment of Molecular Medicine, Sapienza University of Rome, Laboratory Affiliated to Institut Pasteur - Cenci Bolognetti Foundation, Viale Regina Elena 291, 00161 Rome, Italy.ORCID https://orcid.org/0009-0003-9635-1808
Federico PandolfiDepartment of Molecular Medicine, Sapienza University of Rome, Laboratory Affiliated to Institut Pasteur - Cenci Bolognetti Foundation, Viale Regina Elena 291, 00161 Rome, Italy.
Domenico RaimondoDepartment of Molecular Medicine, Sapienza University of Rome, Laboratory Affiliated to Institut Pasteur - Cenci Bolognetti Foundation, Viale Regina Elena 291, 00161 Rome, Italy.ORCID https://orcid.org/0000-0002-1780-7295
Sara MarcheseDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.ORCID https://orcid.org/0000-0002-9722-2616
Andrea MatteviDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.ORCID https://orcid.org/0000-0002-9523-7128
Jihyeon LeeDepartment of Life Science, Ewha Womans University, Seoul 120-750, South Korea.
Minhye ChoiDepartment of Life Science, Ewha Womans University, Seoul 120-750, South Korea.
Yun Soo BaeDepartment of Life Science, Ewha Womans University, Seoul 120-750, South Korea.
Nadya Hristova-AvakumovaDepartment of Medical Physics and Biophysics, Faculty of Medicine, Medical University of Sofia, 2 Zdrave Str., 1431 Sofia, Bulgaria.
Magdalena Kondeva-BurdinaLaboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria.
Denitsa StefanovaLaboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria.
Neda AnastassovaInstitute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Building 9, 1113 Sofia, Bulgaria.ORCID https://orcid.org/0000-0002-2776-0021
Sergio ValenteDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.ORCID https://orcid.org/0000-0002-2241-607X
Dante RotiliDepartment of Science, Roma Tre University, 00146 Rome, Italy.ORCID https://orcid.org/0000-0002-8428-8763
Antonello MaiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.ORCID https://orcid.org/0000-0001-9176-2382

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The convergence of oxidative stress and inflammation drives neurodegeneration and cancer, positioning NADPH oxidases (NOXs) as critical therapeutic targets. Starting from the polyfunctional thiadiazolopyrimidine hit

Indexed as

NeuroprotectionNOX inhibitorsRedox liabilitiesScaffold truncationThiadiazolopyrimidine

Identifiers

PMID42741636
PMCPMC13573257

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.