ArticleSleep advances : a journal of the Sleep Research Society2026
Circadian rhythm amplification in diabetic retinopathy: a pilot study.
Article in Sleep advances : a journal of the Sleep Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06183476 (Circadian Amplification in Diabetic Retinopathy), which is not on this map. Not yet cited in PubMed.
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Circadian Amplification in Diabetic Retinopathy
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13 authors.
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Abstract
Study Objectives: Data suggested that diabetic retinopathy (DR) may be associated with a dysregulated melatonin rhythm and disturbed sleep. This pilot study explored the effects of a novel behavioral intervention "Amplify-RHYTHM" in type 2 diabetes (T2D) with DR. Materials and Methods: Eight T2D persons (5M/3F, mean age 57.2 years) with DR participated in a 6-week "Amplify-RHYTHM" intervention, consisting of sleep stability (remote weekly coaching and educational content), and timed light exposure (morning bright light exposure, evening blue light reduction, and nightly light-blocking sleep mask). Data were collected before and after the intervention. Primary outcomes were insomnia symptoms and 14-day actigraphy-derived sleep parameters. Circadian-related parameters included rest-activity rhythm parameters, dim light melatonin onset ( Results: Compared to baseline, after Amplify-RHYTHM intervention, insomnia symptoms significantly decreased ( Conclusion: Amplify-RHYTHM resulted in less insomnia symptoms, more regular sleep, reduced behavioral circadian fragmentation, and reduced systemic inflammation. These pilot data should be confirmed in a larger, randomized study. Clinical Trials: The study was registered at www.clinicaltrials.gov, NCT06183476.
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