Evidence map›Paper›PMID 42742036›Full record

ArticleChemistry & biodiversity2026

Computational, In Vitro, and In Vivo Evaluation of Benzimidazole-Pyrazole Hybrid Scaffolds as Multi-Target Anti-Ulcer Agents.

Hafiz Aamir Ali Kharl, Abdul Malik, Humaira Nadeem, Mohammad Shamsul Ola, Sara Aiman, Arif Ullah Khan, Muhammad Akmal Farooq, Humaira Muzaffar, Syed Muzzammil Masaud

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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hafiz Aamir Ali KharlRiphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.ORCID https://orcid.org/0000-0002-7365-2937
Abdul MalikDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Humaira NadeemRiphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.ORCID https://orcid.org/0000-0002-0169-0811
Mohammad Shamsul OlaDepartment of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0002-7479-8970
Sara AimanGuangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0000-0002-4115-4984
Arif Ullah KhanRiphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.
Muhammad Akmal FarooqDepartment of Pharmacy, Faculty of Health & Pharmaceutical Sciences, University of Agriculture, Faisalabad, Pakistan.
Humaira MuzaffarDepartment of Physiology, Government College University Faisalabad, Faisalabad, Pakistan.ORCID https://orcid.org/0000-0003-2172-8474
Syed Muzzammil MasaudDepartment of Allied Health Sciences, The Saifee Burhani University, Karachi, Pakistan.ORCID https://orcid.org/0000-0003-4401-6971

Funding

Research Funding Program, King Saud University, Riyadh, Saudi Arabia ORF-2026-376
6 · The paper itself

Abstract

Peptic ulcer disease (PUD) continues to be an important gastrointestinal condition attributed to Helicobacter pylori infection, usage of nonsteroidal anti-inflammatory drugs, oxidative stress, and inflammatory mediators. Although there are available treatments for this condition, side effects, relapse, and safety issues call for development of new multi-target anti-ulcer compounds. In this research, a group of benzimidazole-pyrazole analogs (5a-5j) was designed, synthesized, and studied with the aid of computational and experimental methods. Molecular docking into H

Indexed as

Anti-Ulcer AgentsBenzimidazolesPyrazolesStomach UlcerAnimalsCyclooxygenase 2H(+)-K(+)-Exchanging ATPaseHumansMaleMolecular Docking SimulationMolecular StructureRatsStructure-Activity RelationshipAnti-Ulcer AgentsbenzimidazoleBenzimidazolesCyclooxygenase 2H(+)-K(+)-Exchanging ATPasepyrazolePyrazolesanti‐inflammatoryantioxidantbenzimidazole‐pyrazole hybridsCOX‐2H+/K+ ATPaseMD simulationmolecular dockingpeptic ulcer

Identifiers

PMID42742036
PMCPMC13575949

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.