ReviewScience China. Life sciences2026
Revealing the secrets of quorum sensing: a comprehensive review from signal mechanisms to practical applications.
Review in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quorum sensing (QS), a sophisticated cell-cell communication system in microorganisms, governs collective behaviors such as virulence, biofilm formation, and antibiotic resistance in a population-density-dependent manner. Targeting QS with quorum sensing inhibitors (QSIs) has emerged as a promising anti-virulence strategy to combat bacterial pathogens without exerting lethal selective pressure, thereby potentially curbing the rise of antimicrobial resistance. This review provides an integrated overview of the molecular mechanisms of QS signaling networks in Gram-negative and Gram-positive bacteria, and extends the discussion to cross-kingdom communication and QS-like systems in fungi and bacteriophages. We systematically categorize QSIs based on their origins (plant, microbial, animal, and synthetic) and detail their mechanisms of action, focusing on the interference with autoinducer synthesis, degradation, receptor binding, and downstream signal transduction. Beyond a mere compilation of research advances, we critically evaluate the translational potential of QS interference, highlighting recent applications in clinical medicine (e.g., anti-biofilm coatings), agriculture (biocontrol agents), and environmental engineering (biofouling mitigation). Finally, we identify key challenges such as in vivo efficacy, ecological impact, and the translational gap, and propose future research priorities centered on smart delivery systems, narrow-spectrum inhibitors, and interdisciplinary collaboration. This comprehensive analysis underscores QS interference as a versatile and sustainable strategy, while charting a course for its evolution from a laboratory phenomenon to a practical solution.
Indexed as
Identifiers
42742839What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.