Evidence map›Paper›PMID 42743913›Full record

ArticleCell reports. Medicine2026

A single-dose inhalable rAAV-vectored vaccine against mpox virus.

Zhouguang Jiao, Zhihui Zheng, Yue Xue, Hongjie Wang, Meng Zou, Peijie Qu, Guangzhi Zhang, Jiabo Ding, Yang Liu, Wenjun Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhouguang JiaoNational Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, National Center of Technology Innovation for Animal Model, State Key Laboratory of Respiratory Health and Multimorbidity, and Key Laboratory of Pathogen Infection Prevention and Control, Ministry of Education, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China; College of Basic Medical Science, Hebei University, Baoding 071002, China. Electronic address: jiao_zg@126.com.
Zhihui ZhengNational Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, National Center of Technology Innovation for Animal Model, State Key Laboratory of Respiratory Health and Multimorbidity, and Key Laboratory of Pathogen Infection Prevention and Control, Ministry of Education, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China.
Yue XueCollege of Basic Medical Science, Hebei University, Baoding 071002, China.
Hongjie WangCollege of Basic Medical Science, Hebei University, Baoding 071002, China; Affiliated Hospital of Hebei University, Baoding 071000, China.
Meng ZouNational Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, National Center of Technology Innovation for Animal Model, State Key Laboratory of Respiratory Health and Multimorbidity, and Key Laboratory of Pathogen Infection Prevention and Control, Ministry of Education, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China.
Peijie QuNational Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, National Center of Technology Innovation for Animal Model, State Key Laboratory of Respiratory Health and Multimorbidity, and Key Laboratory of Pathogen Infection Prevention and Control, Ministry of Education, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China.
Guangzhi ZhangInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Jiabo DingInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Yang LiuInstitute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen 518000, China.
Wenjun LiuInstitute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen 518000, China; Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Lei SunLaboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: sunlei362@im.ac.cn.
Pengtao JiaoInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: jiaopengtao@caas.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In response to the global mpox outbreak, an inhalable vaccine platform based on rAAV/DJ vectors is developed. This platform represents a needle-free, single-dose, highly immunogenic defense against monkeypox virus (MPXV) and related orthopoxviruses (OPXVs). Two multivalent vaccines, MV-A (encoding M1R/A35R) and MV-B (encoding A29L/B6R), are engineered, and MV-A, MV-B, and their combination (MV-C) are assessed preclinically. The vector integrates the mucosal adjuvant cholera toxin subunit B (CTB) at the 3' terminus of antigen genes, enabling the sustained production of self-assembled antigen-adjuvant nanoparticles. A single dose induces potent activation of antigen-presenting cells and pulmonary T cell responses, generating lung tissue-resident memory T cells. MV-C induces strong, durable MPXV-specific antibodies in mice and non-human primates, with sera and bronchoalveolar lavage fluid showing high neutralizing activity. Single pulmonary immunization with MV-C establishes a protective mucosal barrier in MPXV-susceptible CAST/EiJ mice and confers protection against OPXVs via respiratory or genital routes. These vaccines hold promise for combating future MPXV variants.

Indexed as

DependovirusGenetic VectorsMpox, MonkeypoxViral VaccinesAdministration, InhalationAnimalsAntibodies, ViralFemaleHumansLungMiceT-LymphocytesAntibodies, ViralViral Vaccinesinhalable vaccinemicempoxmucosal adjuvantnon-human primatesrAAV vector

Identifiers

PMID42743913
PMCPMC13589484

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.