SynthesisInternational journal of obesity (2005)2026
Body mass index and regional brain N-acetylaspartate: a systematic review and meta-analysis of ¹H-MRS studies.
Synthesis in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
BACKGROUND/
objectivesObesity has increasingly been associated with structural brain alterations and cognitive dysfunction; however, the neurometabolic correlates of these findings remain unclear. Proton magnetic resonance spectroscopy ( SUBJECTS/
methodsFollowing PRISMA guidelines, systematic searches of PubMed, Scopus, and Embase identified 23 eligible studies. Separate regional random-effects meta-analyses were conducted for categorical comparisons between groups with normal weight and groups with overweight or obesity, and for continuous associations between BMI and NAA. Supplementary pooled analyses were conducted across brain regions to quantify an overall brain-wide assessment.
resultsHigher BMI was associated with lower NAA concentrations within the frontal region across both categorical (Hedges' g = -0.48, 95% CI [-0.93, -0.03], p = 0.035) and continuous analyses (r = -0.218, 95% CI [-0.323, -0.108], p < 0.001). Additional significant associations were observed in the right hippocampal region in the categorical analysis (Hedges' g = -0.51, 95% CI [-0.84, -0.19], p = 0.002) and the parietal region in the continuous analysis (r = -0.256, 95% CI [-0.463, -0.022], p = 0.032). Pooling results across all regions demonstrated consistently significant negative BMI-NAA associations across continuous analyses of both the lower-bound (most negative) and upper-bound (least negative/most positive) models, while categorical pooled analyses retained significance only within the lower-bound model.
conclusionsIn this meta-analysis, higher BMI was associated with lower neural NAA, most consistently in the frontal regions, but with pooled analyses suggesting more widespread NAA-obesity associations. Findings support the utility of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.