ArticleEMBO reports2026
Light-induced spindle assembly through Aurora A clustering.
Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
3 authors.
Funding
Abstract
Animal cells assemble gigadalton-scale molecular complexes composed of ~200 proteins to build a functional centrosome during mitosis, ensuring faithful chromosome segregation. Although the molecular principles underlying centrosome assembly have been extensively studied, the minimal components required to reconstitute centrosome-like activity in living cells remain unknown. Here, we develop an optogenetic strategy that exploits Aurora A kinase clustering to assemble functional centrosome-like structures in human cells. Remarkably, these light-induced assemblies activate Aurora A, nucleate microtubules, and bypass the requirement for the canonical Aurora A scaffold Cep192. Mechanistically, we identify the evolutionarily conserved Aurora A partner TPX2 as an essential factor for Aurora A cluster-dependent microtubule nucleation. Furthermore, optogenetic Aurora A clustering significantly rescues spindle assembly defects associated with centrosome ablation. We term this approach Light-Induced Spindle Assembly (LISA). By directly coupling Aurora A activity to spatial clustering, LISA defines a minimal and tunable module capable of driving spindle assembly. More broadly, LISA provides a synthetic biology platform for dissecting the fundamental principles of Aurora A-dependent spindle assembly, a prominent feature of mitotic and meiotic spindle formation.
Identifiers
42744924What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.