Evidence map›Paper›PMID 42744953›Full record

ArticleJournal of molecular histology2026

The Expression Pattern of HSF1 and Its Regulating HSP70/TLR2 Expression during MO Infection.

Qinchuan Zhang, Wenyu Fan, Guojie Cheng, Guangxin Zhao, Gang Wang, Sun He, Wenjun Liu, Yanming Sun, Yanbing Zhang

Abstract read
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In one paragraph

Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qinchuan Zhang *College of Animal Science and Technology, Shihezi University, Shihezi, 832003, China.ORCID http://orcid.org/0009-0009-4653-786X
Wenyu Fan *College of Animal Science and Technology, Shihezi University, Shihezi, 832003, China.
Guojie ChengCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China.
Guangxin ZhaoCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China.
Gang WangTECON Pharmaceutical Co., Ltd, Urumqi, 830052, China.
Sun HeTECON Pharmaceutical Co., Ltd, Urumqi, 830052, China.
Wenjun LiuCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China.
Yanming SunCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China. sym@shzu.edu.cn.
Yanbing ZhangCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China. zhangyanbing@shzu.edu.cn.

Funding

National Natural Science Foundation of China 32360901 and 32060133the Natural Science Foundation of Xinjiang 2023LQ03003 and 2022D01B197Xinjiang Corps Guiding Science and Technology Plan Projec 2023ZD042 and 2023ZD043
6 · The paper itself

Abstract

Mycoplasma ovipneumoniae (Mo) is a highly contagious pathogen that causes pneumonia in sheep, seriously threatening the sheep industry. Heat Shock Factor 1 (HSF1) is known to be important for host defense against lung infections, but its role in Mo infection was not understood. This study aimed to clarify HSF1 function during Mo infection. We created an in vivo infection model using Argali Hybrid Sheep and an in vitro model using alveolar macrophages. Immunohistochemistry was applied to check HSF1 expression and location in lung tissues. ELISA tests measured IL-6 and CXCL1 levels in serum and bronchoalveolar lavage fluid (BALF), while Western blot and RT-qPCR assessed HSF1, HSP70, and TLR2 expression in infected lungs and macrophages. Additionally, alveolar macrophages with overexpressed HSF1 were infected with Mo to study HSF1 regulation. Findings showed higher IL-6 and CXCL1 in BALF from infected sheep. Infected lung tissues and macrophages had lower HSF1 and HSP70 expression but higher TLR2 expression. Immunohistochemistry revealed less HSF1 in cell nuclei. Overexpressing HSF1 partly brought back HSP70 levels, reduced TLR2 increase, and improved Mo clearance. HSF1 overexpression enhances the immune response to Mo by controlling the HSP70/TLR2 pathway, offering a scientific foundation for strategies to prevent and control Mo infection.

Indexed as

Gene Expression RegulationHeat Shock Transcription FactorsHSP70 Heat-Shock ProteinsMycoplasma ovipneumoniaePneumonia, MycoplasmaToll-Like Receptor 2AnimalsBronchoalveolar Lavage FluidInterleukin-6LungMacrophages, AlveolarSheepHeat Shock Transcription FactorsHSP70 Heat-Shock ProteinsInterleukin-6Toll-Like Receptor 2Alveolar macrophagesAnti-infectionHeat shock protein 70Heat shock transcription factor 1Mycoplasma ovipneumoniaeToll-like receptor 2

Identifiers

PMID42744953

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.