ArticleObesity surgery2026
Impact of Sleeve Gastrectomy on Obesity Indices, Reproductive Hormones, and Ovarian Reserve Markers: A 12-Month Prospective Study.
Article in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere obesity is associated with hormonal imbalances, hyperandrogenism, and insulin resistance, all of which adversely affect reproductive physiology. Metabolic and bariatric surgery (MBS) produces durable weight loss and metabolic improvement, but its effects on ovarian reserve markers and reproductive hormones in women of reproductive age remain incompletely characterized.
objectiveTo prospectively evaluate the impact of laparoscopic sleeve gastrectomy on obesity indices, reproductive hormones, ovarian reserve markers, and insulin resistance over 12 months in women with severe obesity.
methodsThirty-two women with severe obesity (BMI > 40 kg/m²) undergoing laparoscopic sleeve gastrectomy were assessed at three time points: baseline (2-4 weeks before surgery, prior to the standard pre-operative very-low-calorie diet), 6 months, and 12 months post-operatively. Anthropometric, reproductive-hormone (anti-Müllerian hormone [AMH], antral follicle count [AFC], follicle-stimulating hormone [FSH], luteinizing hormone [LH], estradiol, sex hormone-binding globulin [SHBG], total testosterone, calculated free androgen index [FAI]), and metabolic (HOMA-IR) parameters were measured. Non-parametric tests (Wilcoxon signed-rank, Spearman correlation) were applied.
resultsBMI decreased from 42.38 ± 1.41 to 25.65 ± 0.34 kg/m² at 12 months (p < 0.001). AMH declined from 3.13 ± 0.17 to 2.24 ± 0.44 ng/mL; AFC fell from 11.22 ± 1.60 to 7.16 ± 1.63 (right ovary) and from 11.09 ± 1.30 to 6.19 ± 0.86 (left ovary). FSH, LH, and estradiol increased; SHBG nearly doubled (36.26 → 63.77 nmol/L); total testosterone decreased markedly (27.76 → 9.34 ng/dL); FAI fell from 2.73 ± 0.85 to 0.53 ± 0.19; HOMA-IR declined from 3.94 ± 0.46 to 1.66 ± 0.56 (all p < 0.001). Spearman correlations among change scores showed inverse associations between ΔSHBG and ΔFAI (ρ = -0.420, p = 0.017), and between ΔHOMA-IR and Δtotal testosterone (ρ = -0.374, p = 0.035).
conclusionsSleeve gastrectomy was associated with marked improvements in insulin resistance and androgenic profiles, accompanied by progressive increases in SHBG and reductions in FAI, AMH, and AFC over 12 months. Rather than suggesting deterioration of ovarian function, the overall hormonal pattern appears more consistent with normalization of obesity-associated dysregulated folliculogenesis within an improved metabolic environment. While direct reproductive outcomes were not assessed, these findings support the concept that metabolic bariatric surgery may substantially remodel the endocrine milieu linked to ovarian physiology. Larger prospective studies incorporating fertility-related endpoints are required to clarify the reproductive significance of these changes.
Indexed as
Identifiers
42744983What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.