ArticleSpinal cord2026
Cardiovascular effects of transcutaneous spinal stimulation in persons living with and without spinal cord injury.
Article in Spinal cord, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
STUDY
designCase-control series.
objectivesTo investigate the cardiovascular effects of transcutaneous spinal stimulation (TSS) during orthostatic challenge in persons with and without spinal cord injury (SCI).
settingLaboratory.
methodsEleven persons with cervical SCI and ten persons without SCI participated in this study. Baseline systolic blood pressure (SBP) and heart rate (HR) were measured during an orthostatic challenge (10 min horizontal, 10 min upright). This was repeated with TSS (cathode: T7/T8 or T11/T12) applied when upright, and subsequently for 2 min when horizontal. SBP and HR were compared across groups and experimental conditions with linear mixed models.
resultsWhen upright without TSS, SBP increased in the non-SCI group but decreased in the SCI group (mean difference -19.8 mmHg [95% CI, -33.6 to -6.0]). When upright with TSS, SBP increased in the SCI group, similar to non-SCI group (T7/T8: -6.6 mmHg [-20.4 to 7.3], T11/T12: 2.5 mmHg [-11.3 to 16.3]; non-SCI - SCI). In participants with SCI and orthostatic hypotension (OH), TSS at T11/T12 limited the orthostatic drop by 25.8 mmHg [5.0 to 46.6]. When horizontal, TSS increased SBP in the SCI group (T7/T8: 24.7 mmHg [16.8 to 32.6], T11/T12: 27.2 mmHg [19.3 to 35.1]).
conclusionSpinal stimulation at T11/T12 improved OH in persons with SCI. However, it also increases SBP when applied in a horizontal position, a caution for its clinical use. Future studies in people with SCI should explore the potential mechanisms responsible for these TSS-induced SBP effects.
Identifiers
42744997What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.