Evidence map›Paper›PMID 42745297›Full record

ArticleVeterinary research2026

From immature to mature epithelium: unveiling structural dynamics and transcriptional programs in rainbow trout intestinal barrier.

Andrea Talamilla-Espinoza, Francisca Vera-Tamargo, Mario Caruffo, Miltha Hidalgo, Daniela Ortiz, Leonardo Rodríguez, Dinka Mandakovic, Ana Riveros, Omar Porras, Rodrigo Pulgar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrea Talamilla-EspinozaGenomics and Genetics of Biological Interactions Laboratory, Institute of Nutrition and Food Technology (INTA), University of Chile, El Líbano 5524, 7830490, Santiago, Chile.
Francisca Vera-TamargoGenomics and Genetics of Biological Interactions Laboratory, Institute of Nutrition and Food Technology (INTA), University of Chile, El Líbano 5524, 7830490, Santiago, Chile.
Mario CaruffoGenomics and Genetics of Biological Interactions Laboratory, Institute of Nutrition and Food Technology (INTA), University of Chile, El Líbano 5524, 7830490, Santiago, Chile.
Miltha HidalgoLaboratory for Research in Functional Nutrition, Institute of Nutrition and Food Technology (INTA), University of Chile, El Líbano 5524, 7830490, Santiago, Chile.
Daniela OrtizGenomics and Genetics of Biological Interactions Laboratory, Institute of Nutrition and Food Technology (INTA), University of Chile, El Líbano 5524, 7830490, Santiago, Chile.
Leonardo RodríguezMolecular Mechanisms of Disease Laboratory, Center for Integrative Biology, Universidad Mayor, Camino La Pirámide 5750, 8580745, Santiago, Chile.
Dinka MandakovicGEMA Center for Genomics, Ecology and Environment, Universidad Mayor, Camino La Pirámide 5750, 8580745, Santiago, Chile.
Ana RiverosLaboratorio de Nanobiotecnología y Nanotoxicología, Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Sergio Livingston 1007, 8380492, Santiago, Chile.
Omar PorrasLaboratory for Research in Functional Nutrition, Institute of Nutrition and Food Technology (INTA), University of Chile, El Líbano 5524, 7830490, Santiago, Chile.
Rodrigo PulgarGenomics and Genetics of Biological Interactions Laboratory, Institute of Nutrition and Food Technology (INTA), University of Chile, El Líbano 5524, 7830490, Santiago, Chile. rpulgar@inta.uchile.cl.

Funding

Agencia Nacional de Investigación y Desarrollo Chilean Doctoral Scholarship 21241516Agencia Nacional de Investigación y Desarrollo Fondecyt Regular #1221848Agencia Nacional de Investigación y Desarrollo Fondequip EqM170111
6 · The paper itself

Abstract

The intestinal epithelium is crucial for nutrient absorption, immune defense, and barrier function in farmed fish. However, the molecular mechanisms underlying its development and maturation in salmonids remain poorly characterized, hindering our ability to address pervasive gut health challenges in aquaculture. In this study, we use the RTgutGC cell line to implement an epithelial maturation model with the aim of characterizing the global transcriptional program in rainbow trout (Oncorhynchus mykiss). We evaluated in vitro culture conditions to generate a polarized epithelial barrier with high transepithelial electrical resistance (TEER = 75.8 Ω × cm

Indexed as

Intestinal MucosaOncorhynchus mykissTranscriptomeAnimalsCell LineGene Expression ProfilingIntestinal Barrier Functionepithelial maturationgut healthin vitro intestinal barrier modelrainbow trout (Oncorhynchus mykiss)RTgutGC cell linetranscriptomic profiling

Identifiers

PMID42745297
PMCPMC13576363

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.