Evidence map›Paper›PMID 42745335›Full record

ArticleArthritis research & therapy2026

Macrovascular damage in polymyalgia rheumatica: integrated vascular phenotyping in the POLYMYACARD cohort.

Sarah Wagner, Anna-Lena Zang, Markus Scheppers, Clio Mavragani, Jisna Paul, Ioannis Parodis, Dionysis Nikolopoulos, Andreas Schwarting, Konstantinos Triantafyllias

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sarah WagnerDepartment of Internal Medicine I, Division of Rheumatology and Clinical Immunology, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, Mainz, 55131, Germany. wsarahan@students.uni-mainz.de.ORCID https://orcid.org/0009-0008-3246-9563
Anna-Lena ZangDepartment of Internal Medicine I, Division of Rheumatology and Clinical Immunology, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, Mainz, 55131, Germany.
Markus ScheppersInstitute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Clio MavraganiDepartment of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, 11527, Greece.
Jisna PaulRheumatology and Immunology, Ohio State University Wexner Medical Center, Columbus, OH, USA.
Ioannis ParodisDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Center for Molecular Medicine (CMM), Karolinska University Hospital, Stockholm, Sweden.
Dionysis NikolopoulosDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Center for Molecular Medicine (CMM), Karolinska University Hospital, Stockholm, Sweden.
Andreas SchwartingDepartment of Internal Medicine I, Division of Rheumatology and Clinical Immunology, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, Mainz, 55131, Germany.
Konstantinos TriantafylliasDepartment of Internal Medicine I, Division of Rheumatology and Clinical Immunology, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, Mainz, 55131, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate, for the first time, a wide combination of oscillometric and sonographic markers of macrovascular damage in patients with polymyalgia rheumatica (PMR), using carotid-femoral pulse wave velocity (cfPWV) and carotid greyscale/colour Doppler ultrasound (GSUS/CDUS). Additionally, to explore associations between these markers, traditional cardiovascular (CV) risk factors, and inflammatory parameters.

methodsAortic stiffness was assessed by cfPWV. GSUS measured carotid intima-media thickness (cIMT), plaque presence, and cumulative plaque area. CDUS assessed haemodynamic/compliance surrogates, including resistance index (RI), pulsatility index (PI) in the common (CCA), internal (ICA), and external (ECA) carotid arteries. Multivariable linear regression (MLR) and propensity score matching (PSM) adjusted for confounding.

resultscfPWV was obtained in 72 PMR patients; 26 also underwent GSUS/CDUS. Compared with controls, PMR patients had higher cfPWV (p

conclusionsPatients with PMR exhibited increased aortic stiffness and elevated carotid pulsatility and resistance in the ECA compared with controls, independent of traditional CV risk factors. These non-invasive vascular markers may help identify PMR patients at increased CV risk and support integrated CV risk assessment in clinical care.

Indexed as

Polymyalgia RheumaticaVascular StiffnessAgedCarotid ArteriesCarotid-Femoral Pulse Wave VelocityCarotid Intima-Media ThicknessCohort StudiesFemaleHumansMaleMiddle AgedPhenotypePulse Wave AnalysisRisk FactorsUltrasonography, Doppler, ColorAortic StiffnessCardiovascular RiskCarotid Doppler UltrasoundMacroangiopathyPolymyalgia RheumaticaPulse Wave Velocity

Identifiers

PMID42745335
PMCPMC13576255

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.