ReviewFrontiers in neuroscience2026
Cognitive dysfunction in MASLD is linked to platelet activation.
Review in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Metabolic dysfunction-Associated Steatotic liver disease (MASLD) is one of the most common systemic diseases causing chronic liver diseases. Current evidence indicates that cognitive-related deficits occur frequently in MASLD, causing significant impacts on patients and their families, and even possibly increasing the economic and psychological burdens on healthcare, productivity, and nursing staff. However, there are currently no effective treatment methods. This article reviews the pathogenesis of cognitive dysfunction in MASLD, finding that platelet activation is elevated. Furthermore, recent studies have found that platelets can send and receive signals to the central nervous system (CNS), serving as an important bridge between the brain and peripheral organs. This article reviews changes in platelets associated with MASLD and investigates the role of platelet activation, with the goal of offering novel approaches for diagnosing and treating cognitive dysfunction in MASLD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.