Exercise as a Neurobiological Intervention: Utilizing NAc Circuitry to Combat Addiction.

Kalia N Halim, Caroline E Clark, Matthew C Broomer, Da-Ting Lin

Abstract read

In one paragraph

Article in Addiction neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kalia N HalimIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA.

Caroline E ClarkIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA.

Matthew C BroomerIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA.

Da-Ting LinIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA.

Funding

In vivo imaging of dorsal striatum function in freely behaving miceZIADA000603 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI LIN, DA-TING · 2015 to 2025

$22.3M

Intramural NIH HHS ZIA DA000603

6 · The paper itself

Abstract

Preclinical evidence demonstrates that various forms of exercise can attenuate conditioned place preference (CPP) and self-administration of psychostimulants and opioids. However, the underlying neurobiological mechanisms behind how exercise attenuates drug CPP and self-administration remains unclear. Of particular interest is the role of dopamine receptor-expressing medium spiny neurons (MSNs) in the nucleus accumbens (NAc), as their activity becomes dysregulated after chronic substance use. Functional differences in D1R and D2R MSNs has been observed alongside neurobiological adaptations related to exercise and drug-seeking behaviors. Here, we review mainly preclinical evidence for exercise attenuating psychostimulant and opioid CPP and self-administration along with observed neurobiological adaptations in NAc circuitry. Additionally, we propose utilizing miniscopes to further parse the role of D1R and D2R MSNs during exercise and drug self-administration

Indexed as

addictionexerciseminiscopenucleus accumbensopioidspsychostimulantsself-administration

Identifiers

PMID42746358

DOI10.1016/j.addicn.2026.100276

PMCPMC13577139

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.