ArticleTzu chi medical journal
Statin therapy in end-stage renal disease patients undergoing dialysis: A systematic review and meta-analysis.
Article in Tzu chi medical journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Objectives: Cardiovascular disease is the leading cause of mortality in dialysis patients. While clinical trials have suggested uncertain benefit of statin therapy in this population, several large-scale observational studies have reported an association between statin use and reduced all-cause mortality. To further explore this issue, we aimed to assess the effectiveness of statin therapy in dialysis patients by synthesizing real-world data. Materials and Methods: We systematically searched PubMed and Embase for observational studies comparing adult statin users to nonusers in maintenance dialysis patients. Outcomes included all-cause mortality, cardiovascular death, stroke, myocardial infarction (MI), and major adverse cardiovascular events (MACE). Results: Nineteen studies with 310,370 dialysis patients were included. Statin use was associated with a lower risk of all-cause mortality (adjusted hazard ratio [aHR], 0.82; 95% confidence interval [CI], 0.77-0.87) and cardiovascular death (aHR, 0.83; 95% CI, 0.74-0.94). However, sensitivity analyses showed attenuated associations (aHR, 0.92; 95% CI, 0.89-0.96 for all-cause mortality; aHR, 0.90; 95% CI, 0.82-0.99 for cardiovascular death). No significant associations were observed between statin use and the risk of stroke, MI, or MACE. Conclusion: Statin therapy modestly reduced the risk of all-cause and cardiovascular mortality in patients undergoing maintenance dialysis but was not associated with a reduced risk of stroke, MI, or MACE.
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