Evidence map›Paper›PMID 42746493›Full record

ArticleJournal of clinical & experimental immunology2026

Corrected Version: IL-12 p40 Monomer is Different from Other IL-12 Family Members to Selectively Inhibit IL-12Rβ1 Internalization and Suppress EAE.

Susanta Mondal, Madhuchhanda Kundu, Malabendu Jana, Suresh B Rangasamy, Khushbu K Modi, Roumen Balabanov, Kalipada Pahan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical & experimental immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Susanta MondalDepartment of Neurological Sciences, Rush University Medical Center, Chicago, USA.
Madhuchhanda KunduDepartment of Neurological Sciences, Rush University Medical Center, Chicago, USA.
Malabendu JanaDepartment of Neurological Sciences, Rush University Medical Center, Chicago, USA.
Suresh B RangasamyDepartment of Neurological Sciences, Rush University Medical Center, Chicago, USA.
Khushbu K ModiDepartment of Neurological Sciences, Rush University Medical Center, Chicago, USA.
Roumen BalabanovDepartment of Neurology, Northwestern University, Chicago, USA.
Kalipada PahanDepartment of Neurological Sciences, Rush University Medical Center, Chicago, USA.ORCID 0000-0001-6048-9598

Funding

Characterizing novel hippocampal drugs for Alzheimer's diseaseR01AG050431 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI PAHAN, KALIPADA · 2016 to 2020
$2.1M
Cinnamon, CNTF and EAER01AT006681 · NCCIH · RUSH UNIVERSITY MEDICAL CENTER · PI PAHAN, KALIPADA · 2011 to 2015
$1.8M
Identifying novel PPARß ligands from cerebellumR21NS097426 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI PAHAN, KALIPADA · 2016 to 2017
$388k
BLRD VA I01 BX002174BLRD VA IK6 BX004982NCCIH NIH HHS R01 AT006681NIA NIH HHS R01 AG050431NINDS NIH HHS R21 NS097426
6 · The paper itself

Abstract

Multiple sclerosis (MS) is the most common human demyelinating disease of the CNS. The IL-12 family of cytokines has four members which are IL-12 (p40:p35), IL-23 (p40:p19), the p40 monomer (p40), and the p40 homodimer (p40

Indexed as

DemyelinationEAEIL-12IL-12 p40 homodimerIL-12p40 monomerIL-12Rβ1IL-12Rβ2IL-23Inflammatory infiltrationmultiple sclerosisNeuroprotectionRegulatory T cellsT-helper cells

Identifiers

PMID42746493
PMCPMC13576398

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.