Evidence map›Paper›PMID 42746813›Full record

ReviewJournal of food science2026

Research Progress on Bioactive Peptides From Diverse Sources: Preparation, Structure-Activity Relationship, and Applications.

Po-Rui Liang, Long Pan, Ai-Mei Liao, Yin-Chen Hou, Quan-Ping Liu, Yong-Chao Fan, Xin Wang, Ming Hui, Ji-Hong Huang, Liang Huang and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of food science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Po-Rui LiangHenan Provincial Key Laboratory of Grain Resources Conservation and Utilization, College of Biological Engineering, Henan University of Technology, Zhengzhou, China.
Long PanHenan Provincial Key Laboratory of Grain Resources Conservation and Utilization, College of Biological Engineering, Henan University of Technology, Zhengzhou, China.ORCID https://orcid.org/0000-0002-1149-8081
Ai-Mei LiaoHenan Provincial Key Laboratory of Grain Resources Conservation and Utilization, College of Biological Engineering, Henan University of Technology, Zhengzhou, China.ORCID https://orcid.org/0000-0003-1706-306X
Yin-Chen HouZhengzhou Engineering Research Center of Bioactive Peptides, Zhengzhou, China.
Quan-Ping LiuZhengzhou Engineering Research Center of Bioactive Peptides, Zhengzhou, China.
Yong-Chao FanZhengzhou Engineering Research Center of Bioactive Peptides, Zhengzhou, China.
Xin WangHenan Provincial Key Laboratory of Grain Resources Conservation and Utilization, College of Biological Engineering, Henan University of Technology, Zhengzhou, China.
Ming HuiHenan Provincial Key Laboratory of Grain Resources Conservation and Utilization, College of Biological Engineering, Henan University of Technology, Zhengzhou, China.
Ji-Hong HuangState Key Laboratory of Crop Stress Adaptation and Improvement College of Agriculture, Henan University, Kaifeng, China.
Liang HuangHenan Provincial Key Laboratory of Grain Resources Conservation and Utilization, College of Biological Engineering, Henan University of Technology, Zhengzhou, China.
Na LiuHenan Provincial Key Laboratory of Grain Resources Conservation and Utilization, College of Biological Engineering, Henan University of Technology, Zhengzhou, China.

Funding

Cultivation Programme for Young Backbone Teachers in Henan University of TechnologyCultivation Project of Tuoxin Team in Henan University of Technology 2025TXTD14High-Level Talents Research Fund of HAUT 2020BS064Key Research and Development Project of Henan Province 231111310700
6 · The paper itself

Abstract

Bioactive peptides (BAPs) derived from animal, plant, and microbial proteins have attracted considerable interest because of their potential antioxidant, antihypertensive, antimicrobial, and immunomodulatory activities. However, differences in protein matrix structure, amino acid composition, and non-protein components influence peptide release, structural characteristics, activity, and food-use potential. This review summarizes recent progress in the preparation, structure-activity relationships, and applications of BAPs from diverse sources, with particular emphasis on biomimetic enzymatic hydrolysis and microbial fermentation. The two approaches are compared in terms of substrate suitability, peptide release, downstream processing, sensory properties, scalability, and application scenarios. The review further discusses how molecular weight, amino acid composition, sequence arrangement, conformation, and post-translational modification may contribute to peptide activity, while emphasizing that source-level trends are not universal and require sequence- and assay-specific validation. Finally, current challenges related to gastrointestinal stability, bioaccessibility, safety, regulatory requirements, purification, cost, and commercialization are discussed, together with the potential and limitations of AI-assisted peptide discovery.

Indexed as

PeptidesAnimalsBioactive Peptides, DietaryFermentationHumansHydrolysisStructure-Activity RelationshipBioactive Peptides, DietaryPeptidesbioactive peptidesbiomimetic enzymatic hydrolysisfunctional foodsmicrobial fermentationstructure‐activity relationship

Identifiers

PMID42746813
PMCPMC13579499

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.