Evidence map›Paper›PMID 42746948›Full record

ArticleACS nano2026

Nonsurgical Platelet Membrane-Decorated Gold Yarnball Brain Antenna for In Situ Nitric Oxide Generation and Neuronal Regeneration.

Wan-Chi Pan, Ming-You Shie, Jia-Yue Xu, Thi My Hue Huynh, Hsiu-Ching Liu, Ngoc-Tri Tran, Hoi Man Iao, Hui-Wen Lien, Tsu-Chin Chou, Wen-Hsuan Chiang and 1 more

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Article in ACS nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wan-Chi PanDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu300044, Taiwan.
Ming-You ShieDepartment of Biomedical Engineering, China Medical University, Taichung406040, Taiwan.ORCID 0000-0002-0650-4344
Jia-Yue XuDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu300044, Taiwan.
Thi My Hue HuynhDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu300044, Taiwan.ORCID 0000-0003-1829-7554
Hsiu-Ching LiuDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu300044, Taiwan.
Ngoc-Tri TranDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu300044, Taiwan.
Hoi Man IaoDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu300044, Taiwan.
Hui-Wen LienDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu300044, Taiwan.
Tsu-Chin ChouInstitute of Analytical and Environmental Sciences, National Tsing Hua University, Hsinchu300044, Taiwan.ORCID 0000-0001-8741-7885
Wen-Hsuan ChiangDepartment of Chemical Engineering, National Chung Hsing University, Taichung402, Taiwan.ORCID 0000-0002-2022-0858
Shang-Hsiu HuDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu300044, Taiwan.ORCID 0000-0002-8965-3918

Funding

National Health Research Institutes NHRI-EX113-11111EINational Science and Technology Council of the Republic of China, Taiwan MOST 111-2314-B-007 -003 -MY3, NSTC 112-2321-B-007National Tsing Hua University 112Q2715E1, 112F7MDHE1 and 112F7MDKE1
6 · The paper itself

Abstract

Bioelectronic implants for brain stimulation are widely used to treat neurological disorders and promote neuronal repair; however, their clinical application is limited by invasive surgical implantation. To address this challenge, here, platelet membrane-decorated gold yarnballs double as a brain antenna and a miniaturized chemo-electrical reactor for neuron electric stimulus and gas-controlled release in traumatic brain injury (TBI). The platform consists of a nitric oxide (NO) donor-functionalized platelet membrane (PMNO) conjugated onto a gold yarnball nanoparticle (GNP). Upon exposure to an external high-frequency magnetic field (HFMF), the conductive GNP generates eddy currents that electrically stimulate neural regeneration while simultaneously triggering controlled NO release from PMNO. This dual-mode stimulation enhances neurogenesis, suppresses astrocyte activation, and promotes angiogenesis at the injury site, leading to significantly improved synaptic differentiation and neurite outgrowth of neural stem cells (NSCs). In vivo studies show that combined wireless electrical stimulation and NO signaling suppress inflammation, enhance vascularization, and promote neuronal regeneration in TBI. Behavioral analyses further reveal improved motor coordination and functional recovery in treated mice. The system offers a noninvasive alternative to implanted bioelectronic devices.

Indexed as

gold yarnballsneuronal regenerationnitric oxidenonsurgical brain antennatraumatic brain injurywireless electrical stimulation

Identifiers

PMID42746948
PMCPMC13629675

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.