ArticleActa neurochirurgica2026
Blood C-reactive protein and white blood cells trajectories and associations with clinical parameters and complications in the acute phase after subarachnoid hemorrhage.
Article in Acta neurochirurgica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundInflammation holds a central role in the pathophysiology of subarachnoid hemorrhage (SAH). Two common non-specific inflammatory markers, C - reactive protein (CRP) and White Blood Cells (WBC), were analyzed in blood of SAH patients and their temporal patterns and associations with bleeding severity and complications were studied.
methodsThe charts of 552 SAH patients admitted between 01.01.2015 - 31.12.2019 were retrospectively analyzed through our clinic's database. Blood concentrations of CRP (reference range < 5 mg/L) and WBC counts (reference range 3.5-9 × 10
resultsCRP peaked on Day 4 and WBC on Day 1. Univariate analyses showed that patients with more severe hemorrhage (i.e., identifiable bleeding source, Fisher 3-4, RLS 4-8, EVD indication) and complications (infections, DIND) had significantly higher CRP and WBC values on Day 1 and Day 4. Multivariate analyses showed that DIND was among the variables included in the three models most likely to be associated with higher Day 4 WBC but not CRP values.
conclusionsMore severe bleeding and occurrence of complications in the early phase of SAH are associated with a more intense inflammatory response. An increase in WBC (rather than CRP) around Day 4 post ictus may be associated with the occurrence of DIND.
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