Evidence map›Paper›PMID 42748094›Full record

ArticlePLoS biology2026

Turning a phage anti-defense weapon into an immunity trigger.

Anna B Adelstein, Naama Aviram

Abstract readComment
In one paragraph

Article in PLoS biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Anna B AdelsteinMolecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.
Naama AviramMolecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.ORCID https://orcid.org/0000-0002-0581-958X

Funding

Molecular mechanisms of memory formation and tolerance in CRISPR-Cas systemsR00GM148720 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Naama Aviram · 2025 to 2026
$498k
Molecular mechanisms of memory formation and tolerance in CRISPR-Cas systemsK99GM148720 · NIGMS · ROCKEFELLER UNIVERSITY · PI AVIRAM, NAAMA · 2023 to 2024
$250k
NIGMS NIH HHS K99 GM148720NIGMS NIH HHS R00 GM148720
6 · The paper itself

Abstract

Most bacterial immune systems raise an alarm when they sense a phage. A new study in PLOS Biology shows how type II Panoptes reverses this logic by maintaining a quiet signal and sensing infection through its sudden disappearance.

Indexed as

BacteriaBacteriophagesHost-Pathogen Interactions

Identifiers

PMID42748094
PMCPMC13580996

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.