ArticleProceedings of the National Academy of Sciences of the United States of America2026
TRPV4 mediates low-humidity responses in epidermal keratinocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Environmental humidity is a key determinant of organismal physiology and homeostasis. Although the genetic basis of humidity-driven responses is well established in invertebrates, the molecular and genetic mechanisms by which mammals respond to low humidity remain unclear. Here, using reconstructed 3D epidermal equivalents and a mouse model, we identify transient receptor potential vanilloid 4 (TRPV4) as an important mediator of low-humidity-induced signaling and transcriptional responses in epidermal keratinocytes. In 3D skin models, low-humidity exposure induced rapid water movement, characterized by enhanced apical water loss and concomitant basal-side water uptake within 90 s, followed by TRPV4-dependent Ca
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