Evidence map›Paper›PMID 42748928›Full record

ArticleBiomedical physics & engineering express2026

Entropy of the resting state cortex in epilepsy.

Kirandeep Kaur, Jack O'Brien-Cairney, Gaurav Singh, Manoj Upadhya, Aphrodite Chakraborty, Sarat P Chandra, Harald Prüss, Hans-Christian Kornau, Dietmar Schmitz, Gavin Woodhall and 6 more

Abstract read
In one paragraph

Article in Biomedical physics & engineering express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kirandeep KaurInstitute of Health and Neurodevelopment, College of Health and Life Sciences, Aston University, Birmingham, United Kingdom.ORCID 0000-0002-8846-084X
Jack O'Brien-CairneyInstitute of Health and Neurodevelopment, College of Health and Life Sciences, Aston University, Birmingham, United Kingdom.
Gaurav SinghMEG Resource Facility, National Brain Research Centre, Manesar, India.
Manoj UpadhyaInstitute of Health and Neurodevelopment, College of Health and Life Sciences, Aston University, Birmingham, United Kingdom.ORCID 0000-0002-2032-1472
Aphrodite ChakrabortyDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Sarat P ChandraDepartment of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
Harald PrüssDepartment of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-8283-7976
Hans-Christian KornauGerman Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany.
Dietmar SchmitzGerman Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany.
Gavin WoodhallInstitute of Health and Neurodevelopment, College of Health and Life Sciences, Aston University, Birmingham, United Kingdom.
Richard RoschDepartment for Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience King's College London, London, United Kingdom.
Maia AngelovaAston Digital Futures Institute, College of Engineering and Physical Sciences, Aston University, Birmingham, United Kingdom.
Stefano SeriInstitute of Health and Neurodevelopment, College of Health and Life Sciences, Aston University, Birmingham, United Kingdom.
Manjari TripathiDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Sukhvir K WrightInstitute of Health and Neurodevelopment, College of Health and Life Sciences, Aston University, Birmingham, United Kingdom.
Caroline WittonInstitute of Health and Neurodevelopment, College of Health and Life Sciences, Aston University, Birmingham, United Kingdom.ORCID 0000-0002-5610-4234

Funding

Wellcome Trust
6 · The paper itself

Abstract

Epilepsy has long been conceptualized as a disorder in which aberrant brain dynamics extend beyond the epileptogenic zone. Evidence demonstrates that loss of entropy is a generic feature of pathological dynamics in the brain, including the ictal state. However, the impact of recurrent seizures on entropy in the interictal state remains unknown. Resting state magnetoencephalography (MEG) scans and resection masks of 32 individuals with epilepsy who had Engel I outcome post-surgery were retrospectively retrieved. Using co-registered FreeSurfer parcellations, we reconstructed the source localized MEG time series and computed sample entropy (SE) for 114 regions of interest. We then tested the association of entropy with the resected volume of the brain, and additional clinical variables including the age of seizure onset, seizure frequency and duration of epilepsy. To further understand the temporal relationship between seizure onset and entropy in the interictal state, we collected and computed SE for week-long electroencephalography traces from leucine-rich glioma inactivated 1 monoclonal antibody (LGI1-mAb) rodent models of autoimmune encephalitis (

Indexed as

Cerebral CortexEntropyEpilepsyRestAdolescentAdultAnimalsChildElectroencephalographyFemaleHumansMagnetoencephalographyMaleMiddle AgedRatsRetrospective StudiesEEGentropyepilepsyMEG

Identifiers

PMID42748928
PMCPMC13639335

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.