ArticleNature communications2026
HMGA1-HP1β axis regulates premature aging in Hutchinson-Gilford progeria syndrome through chromatin remodeling.
Qianying Hu, Qian Sun, Weifang Xiang, Zilong Zhou, Hongyan Sun, Yue Hu, Liehao Yang, Chenyu Wang, Fangqing Zhang, Yujia Cong and 3 more
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Qianying Hu *Department of Biobank, China-Japan Union Hospital of Jilin University, Changchun, China.ORCID 0000-0001-5902-6457 Qian Sun *Department of Biobank, China-Japan Union Hospital of Jilin University, Changchun, China.
Weifang Xiang *Key Laboratory of Molecular Epigenetics of Ministry of Education (MOE), Northeast Normal University, Changchun, China.ORCID 0009-0001-5123-6529 Zilong ZhouDepartment of Biobank, China-Japan Union Hospital of Jilin University, Changchun, China.
Hongyan SunDepartment of Biobank, China-Japan Union Hospital of Jilin University, Changchun, China.
Liehao YangDepartment of Biobank, China-Japan Union Hospital of Jilin University, Changchun, China.
Chenyu WangDepartment of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, China.
Fangqing ZhangDepartment of Biobank, China-Japan Union Hospital of Jilin University, Changchun, China.ORCID 0009-0004-5103-5964 Yujia CongDepartment of Biobank, China-Japan Union Hospital of Jilin University, Changchun, China.
Yu ZhangKey Laboratory of Molecular Epigenetics of Ministry of Education (MOE), Northeast Normal University, Changchun, China. zhangy288@nenu.edu.cn.ORCID 0000-0002-3702-6541 Yichuan XiaoCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. ycxiao@sibs.ac.cn.ORCID 0000-0001-7804-6971 Xianling CongDepartment of Biobank, China-Japan Union Hospital of Jilin University, Changchun, China. congxl@jlu.edu.cn.ORCID 0000-0002-5790-4188 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Hutchinson‑Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by mutations in the LMNA gene. High mobility group A1 (HMGA1) exhibits differential expression patterns across aging models. However, its roles and mechanisms in aging remain unclear. Here, we show a positive correlation between HMGA1 and the heterochromatin protein HP1β in multiple tissues of Lmna
Indexed as
Aging, PrematureChromatin Assembly and DisassemblyChromosomal Proteins, Non-HistoneHMGA1a ProteinProgeriaAnimalsCellular SenescenceChromobox Protein Homolog 5Disease Models, AnimalHumansLamin Type AMaleMiceMice, KnockoutChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneHMGA1a ProteinLamin Type A
Identifiers
PMID42749700
PMCPMC13582820
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