ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026
Prognostic determinants of overall, disease-specific and recurrence-free survival in cutaneous squamous cell carcinoma of the head and neck: a single-centre retrospective cohort study.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo identify the independent prognostic determinants of overall, disease-specific and recurrence-free survival in cutaneous squamous cell carcinoma (cSCC) of the head and neck in a single-centre cohort.
methodsEighty patients who underwent surgery for head and neck cSCC between January 2008 and January 2023 were reviewed retrospectively. The effect of clinical, surgical and pathological variables on three endpoints was assessed with univariate Cox regression. To avoid overfitting, the multivariable model for each endpoint was pre-specified with a small number of covariates scaled to the number of events. Kaplan-Meier curves were compared with the log-rank test.
resultsMean age was 71.3 years; 85% were male. Mean follow-up was 46.3 months; 47 patients died (23 from disease) and 41.2% developed recurrence. In pre-specified multivariable models, surgical margin, perineural invasion and nodal stage were independent determinants of all three endpoints. For disease-specific death, the adjusted hazard ratios (aHR) were 4.39 (95% CI 1.77-10.86) per margin category, 5.05 (95% CI 1.99-12.79) for perineural invasion, and 2.43 (95% CI 1.48-4.00) per nodal-stage level. Older age was independent for overall survival only (aHR 1.06; 95% CI 1.03-1.09). The proportional-hazards assumption held, and on internal validation the optimism-corrected c-index remained high (0.74-0.85). Competing-risks analyses confirmed surgical margin, perineural invasion and nodal stage for disease-specific death, while perineural invasion was the most robust recurrence predictor.
conclusionSurgical margin status, perineural invasion and nodal stage were consistent, independent determinants of prognosis that identify high-risk patients; clear margins and accurate nodal assessment should be prioritised, though the retrospective design precludes causal inference.
Indexed as
Identifiers
42749787What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.