ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
FAM134B Restricts African Swine Fever Virus Capsid Assembly via Reticulophagy and Its Antiviral Activity is Antagonized by the Viral Virulence-Associated Factor pMGF300-2R.
Rui Luo, Jing Zhang, Ruojia Huang, Xianfeng Zhang, Lian-Feng Li, Jing Lan, Zhanhao Lu, Yuan Sun, Tao Wang, Hua-Ji Qiu
Abstract read
In one paragraphArticle in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
Rui Luo *State Key Laboratory of Animal Disease Control and Prevention, Professional Laboratory for African Swine Fever (Harbin), National High Containment Facilities for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.ORCID https://orcid.org/0000-0002-8281-6753 Jing Zhang *State Key Laboratory of Animal Disease Control and Prevention, Professional Laboratory for African Swine Fever (Harbin), National High Containment Facilities for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.ORCID https://orcid.org/0009-0000-6920-4712 Ruojia Huang *State Key Laboratory of Animal Disease Control and Prevention, Professional Laboratory for African Swine Fever (Harbin), National High Containment Facilities for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Xianfeng Zhang *State Key Laboratory of Animal Disease Control and Prevention, Professional Laboratory for African Swine Fever (Harbin), National High Containment Facilities for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.ORCID https://orcid.org/0000-0002-7403-7899 Lian-Feng LiState Key Laboratory of Animal Disease Control and Prevention, Professional Laboratory for African Swine Fever (Harbin), National High Containment Facilities for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Jing LanState Key Laboratory of Animal Disease Control and Prevention, Professional Laboratory for African Swine Fever (Harbin), National High Containment Facilities for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Zhanhao LuState Key Laboratory of Animal Disease Control and Prevention, Professional Laboratory for African Swine Fever (Harbin), National High Containment Facilities for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Yuan SunState Key Laboratory of Animal Disease Control and Prevention, Professional Laboratory for African Swine Fever (Harbin), National High Containment Facilities for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Tao WangState Key Laboratory of Animal Disease Control and Prevention, Professional Laboratory for African Swine Fever (Harbin), National High Containment Facilities for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.ORCID https://orcid.org/0000-0002-0834-4372 Hua-Ji QiuState Key Laboratory of Animal Disease Control and Prevention, Professional Laboratory for African Swine Fever (Harbin), National High Containment Facilities for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.ORCID https://orcid.org/0000-0003-4880-5687 Funding
Central Public-interest Scientific Institution Basal Research Fund 1610302025009Heilongjiang Provincial Natural Science Foundation of China YQ2026C016National Natural Science Foundation of China 32202774National Natural Science Foundation of China 32300129National Natural Science Foundation of China 32430102National Natural Science Foundation of China 32573396Youth Innovation Program of the Chinese Academy of Agricultural Sciences Y2025QC19
6 · The paper itselfAbstract
African swine fever (ASF), caused by African swine fever virus (ASFV), is a devastating viral disease in domestic pigs and wild boar. ASFV is a large DNA virus whose capsid assembly takes place within perinuclear viral factories (VFs). Accumulating evidence has demonstrated that reticulophagy confers antiviral activity against multiple RNA viruses. Nevertheless, the roles of reticulophagy in DNA virus replication and viral immunoevasion mechanisms remain largely uncharacterized. Here, we revealed that FAM134B, a reticulophagy receptor, markedly inhibits the maturation of ASFV in VFs. Mechanistically, FAM134B interacts with the major viral capsid proteins p72 and pA137R, facilitating their delivery to lysosomes for reticulophagy-mediated degradation and thus blocking ASFV capsid assembly. Additionally, we found that ASFV exploits its virulence-associated factor pMGF300-2R to target FAM134B and enhance viral replication. Further investigations revealed that pMGF300-2R binds to FAM134B and triggers its autophagic degradation via the C-terminal LC3-interacting region (LIR) motif. Importantly, the MGF300-2R-deleted ASFV mutant exhibited significantly reduced replication and virulence compared with wild-type ASFV in pigs, which was attributed to increased FAM134B expression. Collectively, this study establishes the first mechanistic link between reticulophagy and DNA virus replication and underscores the critical role of FAM134B-mediated reticulophagy in host defense against ASFV infection.
Indexed as
African swine fever virusFAM134BLC3‐interacting region (LIR)p72pA137RpMGF300‐2Rreticulophagy
Identifiers
PMID42750100
PMCPMC13583106
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