ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Sonogenetics Nanomedicine Activates the cGAS-STING Pathway for Immunotherapy of Triple-Negative Breast Cancer.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Due to pronounced tumor heterogeneity and the lack of effective therapeutic options, triple-negative breast cancer (TNBC) remains a formidable clinical challenge for the development of effective medicines. Here, we report a HER3-targeted sonogenetic mechano-immunomodulatory nanoplatform (HSMIN-LNP), achieving integrated synergistic therapy for TNBC. HSMIN-LNP employs a de novo AI-designed HER3-targeting miniprotein (HTIM) and co-delivers the TRPV4 (mechanosensory) plasmid together with an NFAT-promoted IL-15 gene. The results demonstrated that HTIM directly bound and suppressed HER3 signaling, inhibiting the downstream PI3K/AKT/mTOR pathway. This process markedly impaired tumor cell migratory capacity. The NPs also exhibited a uniform and stable nanostructure with high plasmid encapsulation efficiency and enabled ultrasound (US)-triggered local IL-15 induction through TRPV4-mediated Ca
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