Magneto-Sono-Enhanced Nanozyme Catalysis Drives ROS-Mediated Pathogen Killing and Mitophagy-Linked Inflammation Control in Bacterial Pneumonia.

Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu

Abstract read

In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Xiaofeng Luo *State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, The Affiliated Sanya Central Hospital of Hainan University, School of Pharmaceutical Sciences, Hainan University, Sanya, China.

Yundi Wu *State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, The Affiliated Sanya Central Hospital of Hainan University, School of Pharmaceutical Sciences, Hainan University, Sanya, China.

Shuai ZhangState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, The Affiliated Sanya Central Hospital of Hainan University, School of Pharmaceutical Sciences, Hainan University, Sanya, China.

Huanran QuState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, The Affiliated Sanya Central Hospital of Hainan University, School of Pharmaceutical Sciences, Hainan University, Sanya, China.

Shiyang ShaoSchool of Materials Science and Engineering, Hainan University, Haikou, China.

Jianqiang ChenEngineering Research Center For Hainan Biological Sample Resources of Major Diseases, Key Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital, Hainan Medical University, Haikou, China.

Xilong WuState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, The Affiliated Sanya Central Hospital of Hainan University, School of Pharmaceutical Sciences, Hainan University, Sanya, China.ORCID https://orcid.org/0000-0002-5689-538X

Funding

Collaborative Innovation Center Research Project in Hainan University XTCX2022JKB06Hainan Province Science and Technology Special Fund ZDYF2023SHFZ142Hainan Province Science and Technology Special Fund ZDYF2025SHFZ026Nanhai Innovation Talent Program (Education Sector) of Hainan Province 2025NHYC403National Natural Science Foundation of China 22065011National Natural Science Foundation of China 22665017National Natural Science Foundation of China 52073077Open Foundation of Key Laboratory of Emergency and Trauma of Ministry of Education in Hainan Medical University KLET-202606

6 · The paper itself

Abstract

Bacterial pneumonia treatment faces significant challenges due to uncontrolled inflammation and rising antibiotic resistance. Excessive inflammatory cytokine release and mitochondrial dysfunction exacerbate tissue damage, contributing to the disease's progression. Mitophagy, a process that eliminates dysfunctional mitochondria, helps regulate reactive oxygen species (ROS) levels and suppress inflammation. However, efficient bacteria clearance remains critical for effective inflammatory modulation. Traditional antibiotics struggle against resistant bacteria, necessitating alternative approaches. ROS-based nanocatalytic therapies, particularly nanozymes, show potential for overcoming ROS generation limitations through external stimuli like ultrasound and magnetic fields. This study designs a sono-magneto-responsive nanozyme (BN@NF) composed of boron nanosheets (BN) and neodymium-doped iron phosphide (Nd:Fe

Indexed as

bacterial pneumoniamagnetothermal therapymitophagynanozyme catalysisnebulization deliverysonodynamic therapy

Identifiers

PMID42750269

DOI10.1002/advs.77785

PMCPMC13583241

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.