Evidence map›Paper›PMID 42750338›Full record

ReviewWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

From Dilemma to Breakthrough: Prospects for Clinical Application of Exosome-Hydrogel Systems in Diabetic Wound Repair.

Changna Han, Luning He, Zhu Qian, Siqi Wang, Sen Mu, Aiyang Tong, Jingli Wang, Junwei Xie, Ji Li

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Changna HanDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Luning HeDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Zhu QianDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Siqi WangDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Sen MuDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Aiyang TongDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Jingli WangDepartment of Rehabilitation, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People's Republic of China.
Junwei XieDepartment of Thoracic Surgery, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning Province, People's Republic of China.ORCID https://orcid.org/0009-0005-2567-5869
Ji LiDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.ORCID https://orcid.org/0000-0002-8156-3811

Funding

Doctoral Start-up Foundation of Liaoning Province 2024-BS-071National Natural Science Foundation of China 82304425
6 · The paper itself

Abstract

Diabetic wounds are refractory due to persistent inflammation and impaired angiogenesis, with traditional treatments having limited therapeutic effects. As promising cell-free therapeutic agents, exosomes can regulate wound inflammation and accelerate angiogenesis, while their clinical application is restricted by rapid in vivo clearance and short wound retention time. Functional hydrogels with excellent biocompatibility and sustained-release performance serve as ideal exosome carriers to construct intelligent composite dressings that break multiple healing barriers. This review summarizes the pathological mechanisms of diabetic wounds, the repair mechanisms of exosomes, and the fabrication strategies of exosome-loaded hydrogels. It also analyzes current challenges and prospects for the artificial intelligence-empowered research and clinical translation, providing theoretical references for the development of novel diabetic wound repair materials.

Indexed as

Diabetes ComplicationsDiabetes MellitusExosomesHydrogelsWound HealingAnimalsHumansHydrogels

Identifiers

PMID42750338
PMCPMC13583396

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.