CHAC1-linked NRF2 protein expression participates in pancreatic islet protection by dextrorphan.

Celine Weippert, Philip Kirschner, Barbara Bartosinska, Andrea Köster, Daniel Eberhard, Eckhard Lammert

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Celine WeippertInstitute of Metabolic Physiology, Heinrich Heine University, 40225 Düsseldorf, Germany.

Philip KirschnerInstitute of Metabolic Physiology, Heinrich Heine University, 40225 Düsseldorf, Germany.

Barbara BartosinskaInstitute of Metabolic Physiology, Heinrich Heine University, 40225 Düsseldorf, Germany.

Andrea KösterInstitute of Metabolic Physiology, Heinrich Heine University, 40225 Düsseldorf, Germany.

Daniel EberhardInstitute of Metabolic Physiology, Heinrich Heine University, 40225 Düsseldorf, Germany.

Eckhard LammertInstitute of Metabolic Physiology, Heinrich Heine University, 40225 Düsseldorf, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The N-methyl-D-aspartate (NMDA) receptor antagonist dextrorphan (DXO) protects pancreatic islets from cell death induced by streptozotocin (STZ), inflammatory cytokines, reactive oxygen species (ROS), as well as in multiple mouse models of diabetes. Here we show that cytoprotective concentrations of DXO upregulate the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2), driving the expression of its downstream target genes. Paradoxically, DXO also increases the expression of the pro-apoptotic factor CHAC1 (chaC glutathione-specific γ-glutamylcyclotransferase 1). To investigate its role, we silenced

Indexed as

beta-cell survivalcellular stress responsepancreatic beta cellredox homeostasis

Identifiers

PMID42750925

DOI10.1016/j.isci.2026.117474

PMCPMC13578463

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.